Dose-survival curves for murine hematopoietic stem cells and transplanted syngeneic lymphoma cells were constructed for a variety of alkylating agents administered in vivo. A comparison of the slopes of the dose-survival curves, defined as the efficacy ratio, provided a quantitative measure of the differential sensitivity of these two cell populations to a given alkylating agent. Nitrogen musta...

North-East Arctic cod is shared by Russia and Norway. Taking its multi-cohort structure into account, how would optimal management look like? How would non-cooperative exploitation limit the obtainable profits? To which extent could the strategic situation explain today’s over-harvesting? Simulation of a detailed bioeconomic model reveals that the mesh size should be significantly increased, re...

The 'watch dog' role of the media, the impact of migration processes, health care access for children in developing countries, mitigation of the effects of Global Warming are typical examples of governance issues – issues to be tackled at the base; issues to be solved by creating and implementing effective policy. students to pave the road for innovative policy developments in Europe and the wo...

Public opinion formation plays a very important role in economic policy development. Opinions put forward in various social platforms offered by the media and the Internet have a large impact on international treaty negotiations. In particular this seems to be the case for international negotiations regarding the abatement of greenhouse gasses. In this paper we argue that social opinion formati...

Observational studies have suggested that postmenopausal hormone replacement therapy (HRT) may improve cognitive function, but data from randomized clinical trials have been sparse and inconclusive. The effects of HRT on dementia and mild cognitive impairment were assessed in a subgroup of participants in the Women's Health Initiative Memory Study (WHIMS) (a multicenter, randomized, double-blin...

OBJECTIVE Ceramide is now recognized as a negative regulator of insulin signaling by impairing protein kinase B (PKB)/Akt activation. In different cells, two distinct mechanisms have been proposed to mediate ceramide inhibition of PKB/Akt: one involving atypical protein kinase C zeta (PKCzeta) and the other the protein phosphatase-2 (PP2A). We hypothesized that ceramide action through PKCzeta o...

ACKNOWLEDGEMENTS Without the help and support from a large number of people, this work would not have been possible. First of all, I would like to thank Prof. Laurence Jacobs for making this exchange possible and for being a great advisor, supporter, teacher and friend. He opened a new door to ultrasonic wave propagation I might not have entered without him. A huge 'Thank You' goes to Dr. Jin-Y...

Oestrogen therapy is the gold standard treatment for hot flushes/night sweats, but it and oestrogen/progestin are not suitable for all women. MPA (medroxyprogesterone acetate) reduces hot flushes, but its effectiveness compared with oestrogen is unknown. In the present study, oral oestrogen [CEE (conjugated equine oestrogen)] and MPA were compared for their effects on hot flushes in a planned a...