OBJECTIVES To compare the efficacy and safety of lumiracoxib with placebo and celecoxib for osteoarthritis OA in a 13 week, multicentre, randomised, double blind study. METHODS After a 37 day washout period for nonsteroidal antiinflammatory drugs, 1702 patients with knee OA were randomised to lumiracoxib 200 or 400 mg once daily od, celecoxib 200 mg od, or placebo 2221. A visual analogue scal...

GaSb inversion-mode PMOSFETs with atomiclayer-deposited (ALD) Al2O3 as gate dielectric are demonstrated. A 0.75-μm-gate-length device has a maximum drain current of 70 mA/mm, a transconductance of 26 mS/mm, and a hole inversion mobility of 200 cm/V · s. The OFF-state performance is improved by reducing the ALD growth temperature from 300 ◦C to 200 ◦C. The measured interface trap distribution sh...

A heterodimeric form, CA, of protein-serine/threonine phosphatase (PP) 2A purified from human erythrocytes was dissociated into a 34-kDa catalytic subunit C and 63-kDa inactive subunit A by Sephacryl S-200 gel filtration in the presence of 6 M urea. Reassociation of the C- and A-subunits in the absence of urea suppressed the PP activity of the C subunit toward phosphorylase a, P-H2B histone, an...

High-speed terahertz (THz) reflection three-dimensional (3D) imaging is demonstrated using electronically-controlled optical sampling (ECOPS) and beam steering. ECOPS measurement is used for scanning an axial range of 7.8 mm in free space at 1 kHz scan rate while a transverse range of 100 × 100 mm(2) is scanned using beam steering instead of moving an imaging target. Telecentric f-θ lenses with...

In this study, the kinetics of the acid catalyzed hydrolysis of microcrystalline cellulose (Avicel PH101) to levulinic (LA) and formic (FA) acids was investigated in a batch reactor over the following range of conditions: 160–200 C, hydrochloric acid concentrations of 0.309–0.927 M (11.3–33.8 g/l), cellulose concentrations of 49.8–149 mM (8.06–24.1 g/l), and residence times of 0–50 min. The max...

Sample preparation and tryptic digestion of the phosphorylated and nonphosphorylated AP2 complex for mass spectrometry. AP2 samples were stored at 4°C and buffer-exchanged twice with 200 mM ammonium acetate, pH 7.5 using microcentrifuge columns (Micro Bio-spin 6, Bio-Rad) before analysis. Buffer exchange and sample introduction were conducted at room temperature. Dissociation of the complex was...

FIGURE 1. Effect 0fGDPBS, CTP.,S, and GTP on 3H-mucin release. Confluent cultures (16 mm) which had been pretreated with streptolysin 0 were pulsed with H-glucosamine for 24 h and chased for 30 mm in the presence of the nucleotides (200 p.M GTP.,S, 200 iM GDP,,S, and 200 M GTP). In panel A, GDP,,S was added immediately before GTP S. Data represent means ± SE of4 culture dishes. Mucin release by...

This research was conducted with the aim of knowing Effect using silica sand before and after physical activation on acceleration a 4-stroke gasoline motorcycle engine. by testing 0 – 80 km/hour 40 variations in composition tapioca pellet mixture (1%, 2%, 3%) temperature (150?C, 200?). C, 250?C). The pellets used this study were 10 mm diameter thickness 3 mm, which had been activated for 60 min...

AIMS To create and use a geometrical model for sentinel lymph node (SLN) histopathology in breast cancer. METHODS The model involves a spherical metastasis randomly situated in an SLN. Two extreme situations are taken as the starting points. In one of these, the metastasis is seen in its largest dimension, whereas in the other it is only just visible, approximating 0 mm in size. Intermediate ...