نتایج جستجو برای: 1protein kinase ck2reactive oxygen species
تعداد نتایج: 914541 فیلتر نتایج به سال:
ABSTRACT The Asian traditional medicinal plant Acorus calamus and its component α-asarone exhibited various biological activities, such as antiinflammation antioxidant effects. In the present study, we investigated in vitro effects of A. extract on oxidative stress- endoplasmic reticulum (ER) stress–induced cell death hippocampal HT22 cells. both significantly suppressed induced by stress induc...
Background: Nerol was reported as a natural anti-oxidant product and its protective effects against cardiovascular diseases have been documented. Our current study designed to explore the cardioprotective effect of on hypoxia/reoxygenation (H/R)-induced production reactive oxygen species (ROS) cell apoptosis in H9c2 cells. The potential molecular mechanisms were further investigated.
 Meth...
Objective(s): Iranian crack (IC) is a heroin-based substance manifesting various pathologic side effects. Herein, we aimed to investigate the mechanism of IC-induced liver injuries in Wistar rats. Materials and Methods: Twenty male Wistar rats were randomly divided into two groups: control, and IC (0.9 mg/kg/day/IP, for 30 days). Mitochondrial reactive oxygen species (ROS) production was measur...
The thyroid gland and hormones control a multitude of homeostatic functions including maintenance fluid electrolyte balance normal functioning the kidneys. Thyroid dysfunction alters sytemic hemodynamic metabolic balance, thereby affecting kidney. In this study, we aimed to identify characterize urinary proteome patients with hypothyroidism. An untargeted proteomic approach network analysis was...
Reactive oxygen species cause to release of dormancy in many plants such as sunflower seeds. This study investigated in order to evaluation role of reactive oxygen species germination and lipid proxidation in sunflower seeds. This study was performed in two separate experiments, each in a completely randomized design with factorial design with four replications. In both experiments, uses from ...
The mitochondrial enzyme monoamine oxidase (MAO), its isoform MAO-A, plays a major role in reactive oxygen species-dependent cardiomyocyte apoptosis and postischemic cardiac damage. In the current study, we investigated whether sphingolipid metabolism can account for mediating MAO-A- and reactive oxygen species-dependent cardiomyocyte apoptosis. In H9c2 cardiomyoblasts, MAO-A-dependent reactive...
BACKGROUND Atrial fibrillation (AF) is a growing public health problem without adequate therapies. Angiotensin II and reactive oxygen species are validated risk factors for AF in patients, but the molecular pathways connecting reactive oxygen species and AF are unknown. The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) has recently emerged as a reactive oxygen species-activated proarrh...
BACKGROUND Anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3 (PR3) are postulated to injure vascular endothelium by inducing cytokine-primed neutrophils to release proteolytic enzymes and generate reactive oxygen species. Anti-PR3 induce exocytosis, and since priming is associated with upregulation of plasma membrane proteins by exocytosis of intracellular granules, we tested t...
BACKGROUND Thioredoxin 2 (Trx2) is a key mitochondrial protein that regulates cellular redox and survival by suppressing mitochondrial reactive oxygen species generation and by inhibiting apoptosis stress kinase-1 (ASK1)-dependent apoptotic signaling. To date, the role of the mitochondrial Trx2 system in heart failure pathogenesis has not been investigated. METHODS AND RESULTS Western blot an...
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