Chronic alcohol consumption leads to inflammation and cirrhosis of the liver. In this study, we observed that liver sinusoidal endothelial cells (LSEC) derived from ethanol-fed rats showed several fold increases in the mRNA expression of endothelin-1 (ET-1), hypoxia-inducible factor-1alpha (HIF-1alpha), and inflammatory cytochemokines compared with control rat LSEC. We also observed the same re...

Klas Tybrandt, Karin C Larsson, Sindhulakshmi Kurup, Daniel Simon, Peter Kjall, Joakim Isaksson, Mats Sandberg, Edwin Jager, Agneta Richter-Dahlfors and Magnus Berggren, Translating Electronic Currents to Precise Acetylcholine-Induced Neuronal Signaling Using an Organic Electrophoretic Delivery Device, 2009, Advanced Materials, (21), 44, 4442. http://dx.doi.org/10.1002/adma.200900187 Copyright:...

Publication date: 2014 Document Version Early version, also known as pre-print Citation for published version (APA): Mortensen, K. (2014). Characterization of Polymer Blends: Miscibility, Morphology and Interfaces. In Characterization of Polymer Blends and Block Copolymers by Neutron Scattering: Miscibility and Nanoscale Morphology (Wiely-VCH Verlag ed., Chapter Chapter 7, pp. 237-268). Wiley-VCH.

The aim of the study was to determine the optimum concentration of the mare serum (MS) for sheep in vitro oocyte maturation. Sheep ovaries were collected from a local abattoir and transported within 1 h to the laboratory in a warm saline solution (30 – 35C), supplemented with 100 IU penicillin G and 100 g streptomycin sulfate/ml. Cumulus-oocyte complexes (COC’s) were obtained by slicing of foll...

OBJECTIVE Many patients with irritable bowel syndrome IBS not only have abdominal pain but also may suffer from visceral hypersensitivity and heighted visceral nociception. Moreover, IBS has few effective therapeutic agents and mechanisms of disease are unclear. Our goals were to (i) identify microRNA (miRNA) expression, signalling and targets in human colon (controls; patients with IBS); (ii) ...

PURPOSE To investigate the roles of BCL2, MCL1, and BCL-XL in the survival of diffuse large B-cell lymphoma (DLBCL). EXPERIMENTAL DESIGNS Immunohistochemical analysis of 105 primary DLBCL samples, and Western blot analysis of 18 DLBCL cell lines for the expression of BCL2, MCL1, and BCL-XL. Pharmacologic targeting of BCL2, MCL1, and BCL-XL with ABT-199, homoharringtonine (HHT), and ABT-737. A...

BACKGROUND The goal of antiretroviral therapy (ART) is to reduce HIV-related morbidity and mortality by suppressing HIV replication. The prognostic value of persistent low-level viremia (LLV), particularly for clinical outcomes, is unknown. OBJECTIVE Assess the association of different levels of LLV with virological failure, AIDS event, and death among HIV-infected patients receiving combinat...

While the molecular structures of angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) are very similar, they are also slightly different. Although each ARB has been shown to exhibit a unique mode of binding to AT1 receptor, different positions of the AT1 receptor have been analyzed and computational modeling has been performed using different crystal structures for the receptor as a t...

BACKGROUND The purpose of this study was to examine the emergency physician (EP) practice of prescribing prophylactic antibiotics for patients with oral lacerations. A secondary outcome measure was the infection rate of those who were or were not prescribed antibiotics. METHODS The study was a retrospective chart review of 323 patients who presented to a large urban emergency department (ED) ...