OPULATIONS of sexual, diploid, and outbreeding organisms contain con‘cealed genetic loads, which can be greatly increased by radiation exposures. The influence of radiation-induced genetic loads on fitness has been studied in Drosophila (WALLACE 1956,1958; STONE, WHEELER and WILSON 1962; CARSON 1964), swine (Cox 1964), mice (GOWEN and STADLER 1964; SEARLE 1964; SPALDING. BROOKS and MCWILLIAMS 1...

Pronethalol, a beta-adrenergic-blocking agent, has been used successfully in the treatment of supraventricular and ventricular arrhythmias (Stock and Dale, 1963; Grandjean and Rivier, 1963; Johnstone, 1964; Payne and Senfield, 1964). Vaughan Williams and Sekiya (1963) demonstrated that ventricular fibrillation produced in guinea-pigs by the infusion of ouabain could be prevented and controlled ...

5’ Lee, M., Harris, K. & Trowbridge, H. (1964). J. Nutr. 84, 136. Ludwig, A., Weis, J. & Korte, F. (1964). Life Sci. 3, 123. Marth, E. H. (1965). Residue Rev. 9, I . Mills, P. A. (1963). r. Ass. off. agric. Chem. 46, 672. Moore, N. W. & Walker, C. H. (1964). Nature, Lund., 201, 1072. Ortelee, M. F. (1958). Archs ind. Hlth, 18. 433. Phillips, W. E. J. (1963). Can. J. Biochem. Physiol. 41, 1793. ...

a causal relationship between oral contraceptive drugs and thrombotic disease (Chicago Conference, 1962; Mills, 1964). Laboratory investigations into the possible changes in the coagulation balance which might significantly add to the risk of thrombosis have yielded conflicting results. Phillips et al. (1961) studied the effects of exogenous steroids on the clotting mechanism of human subjects....

It is now generally accepted that hyperaldosteronism is associated with such oedematous states as the nephrotic syndrome, cirrhosis of the liver, and congestive heart failure (Wolff et al., 1964); that the renin-angiotensin system plays an important role in the regulation of aldosterone secretion (Genest et al., 1960; Laragh et al., 1960; Carpenter, Davis, and Ayers, 1961; Bartter et al., 1961;...

Incidence of the Disease Among childhood infections those of the urinary tract are second in frequency only to respiratory infections, and are the commonest bacterial infections under two years of age (Pryles, 1960; Deluca, Fisher and Swenson, 1963). The incidence of overt urinary infections in the general population is estimated at 8 per 1,000 per annum (Percival, Brumfitt and Louvois, 1964), ...

En 1964, Emile Benveniste deplorait l’absence de documentation eclairant la decennie (1880-1891) que Ferdinand Saussure a passee Paris : « pas un souvenir lui ne subsiste dans une tete d’homme, ecrivait-il, pas ligne tracee sa main » (Benveniste 1964 : 22). Ce constat est, depuis quelques annees deja, caduc. Grâce l’entreprise biographique John Joseph et aux travaux recents menes sur les archiv...

It is now generally accepted that hyperaldosteronism is associated with such oedematous states as the nephrotic syndrome, cirrhosis of the liver, and congestive heart failure (Wolff et al., 1964); that the renin-angiotensin system plays an important role in the regulation of aldosterone secretion (Genest et al., 1960; Laragh et al., 1960; Carpenter, Davis, and Ayers, 1961; Bartter et al., 1961;...

Earlier investigations have shown that actinomycin D, which inhibits DNA-dependent RNA synthesis (Reich et al., 1961) by binding to DNA (Kirk, 1960), has a profound effect on the nuclear structure of cells. Some of the most striking consequences are visible in the nucleoli which exhibit both a decrease in size and a variety of fine structural changes (Journey and Goldstein, 1961; Reynolds et al...