INTRODUCTION The aim of this study was to evaluate the health-related quality of life (HRQoL) of Malaysian patients with type 2 diabetes mellitus (T2DM) who have cardiovascular disease (CVD), as well as identify the determinants of HRQoL among this cohort of patients. METHODS This study was an analytical cross-sectional study involving 313 patients aged 30-78 years (150 men, 163 women; mean a...

BACKGROUND Home haemodialysis (HHD) and self-care satellite dialyses (SHD) have been suggested to offer significant benefits over conventional in-centre haemodialysis. However, little is known about differences between these two modalities. The purpose of the study was to analyse costs and health-related quality of life (HRQoL) of HHD and SHD. METHODS On 15 October 2004, a total of 65 patient...

Thiazolidinediones (TZDs) are synthetic peroxisome proliferator-activated receptor-gamma (PPARgamma) ligands that are widely used in type II diabetes treatment. In addition to their ability to improve glucose homeostasis, TZDs possess anti-inflammatory properties and inhibit growth of many cells, particularly cancerous airway epithelial cells. However, the functional effects of PPARgamma ligand...

Stress exposure leads to oxidative/nitrosative and neuroinflammatory changes that have been shown to be regulated by antiinflammatory pathways in the brain. In particular, acute restraint stress is followed by cyclooxygenase (COX)-2 up-regulation and subsequent proinflammatory prostaglandin (PG) E2 release in rat brain cortex. Concomitantly, the synthesis of the antiinflammatory prostaglandin 1...

ABSTRACT KH 15D is a system that consists of young, eccentric binary, and circumbinary disc obscures the binary as precesses. We develop self-consistent model provides reasonable fit to photometric variability was observed in over past 60 yr. Our suggests has an inner edge rin ? 1 au, outer rout ? few misaligned relative stellar by ?5–16°, with more inclined than edge. The difference between in...

KH 15D contains a circumbinary disk that is tilted relative to the orbital plane of central binary. The precession and motion binary together produce rich phenomena in photometric light curve. In this work, we present discovery preliminary analysis two objects resemble key features from Zwicky Transient Facility. These new objects, Bernhard-1 Bernhard-2, show large-amplitude ($>1.5\,$mag), long...

3'-Deoxy-4'-azaribonucleosides (15a-d) were synthesized starting from the commercially available (4R)-trans-4-hydroxy-l-proline 7. From biological evaluations, 15b and 15d emerged as potent inhibitors of HCV replication on a replicon assay. These findings demonstrate that synthesized pyrrolidine nucleosides represent a new template for antiviral or other biological studies and could be consider...