I was very honored to receive the University of California, San Francisco, and the International Society of Pharmacometrics Lewis Sheiner lecturer award in May 2013. In the present perspective, I outline the main points of my lecture at the American Conference of Pharmacometrics (slides in Supplementary Material 1). I first emphasize the scientific contributions of Lewis Sheiner as a quantitati...

8-puzzle is typically solved by heuristic search. Real-time heuristic search usually gives better results when searching deeper. But sometimes deeper search leads to worse results than shallower which is a phenomenon called search pathology. In this paper we present the results of our investigation of the causes for pathology in 8-puzzle and some of its variations.

CuCl has been successfully immobilized on a novel diamide modified SBA-15, and proven to be an efficient heterogenized catalyst for the oxidative carbonylation of methanol to dimethylcarbonate.

The relationship between stimulation frequency and contraction was established for ventricular strips from rainbow trout heart at 5, 15 and 25 degrees C. Compared to mammalian species, changes in temperature had little impact on force development in trout ventricle at physiologically relevant stimulation frequencies. However, the force-frequency relationship was changed from a biphasic response...

We study a simple, general framework for search called bootstrap search, which is defined as global search using only a local search procedure along with some memory for learning intermediate subgoals. We present a simple algorithm for bootstrap search, and provide some initial theory on its performance. In our theoretical analysis, we develop a random digraph problem model and use it to make s...

In 2007, Alex Rodriguez signed a $275 million, ten-year contract with the New York Yankees, setting the record at the time for largest sports contract in history.1 Since then, he has faced many allegations of performance enhancing drug (―PED‖) use, one of which he confirmed through a public admission.2 Regardless of these allegations and admissions, Rodriguez continues to reap the benefits of h...

Over the last three decades, rapidly increasing interest has been shown, and a great growth has occurred in publications and new journals, related to assessing spiritual health and well-being. Most attention has been paid to university students (many of whom participate in research projects to gain credit points) and adults, many of whom have been in poor states of health. However, assessment o...