BACKGROUND Direct hemoperfusion therapy with polymyxin B immobilized fiber cartridges (PMX-DHP) is widely used for septic shock in Japan and parts of Europe. Although this treatment is usually administered for 2 h, the optimal duration has not been established. METHODS This retrospective study compared the effects of prolonged and conventional PMX-DHP durations (2 and 12 h, respectively) for ...

Synthesis of organic compounds using nano-catalysts is more and more attention due to the numerous advantages such as cost-effectiveness, high catalytic activity, ease of product separation, recovery of the catalyst, repeated recycling potential and good stability. In this work, TiCl2/nano-γ-Al2O3, as a novel type of green heterogeneous solid acid was prepared by the immobilization of TiCl2 on ...

Phosphosulfonic acid (PSA) was found to be an efficient catalyst for the one-pot three-component Hantzsch condensation reaction of arylaldehydes, ethylacetoacetate and ammonium acetate to afford the corresponding 1,4-dihydropyridine and polyhydroquinoline derivatives in high yields. PSA was also applied for the one-pot preparation of polyhydroquinolines via four-component reaction of a...

The silyl enol ether derivatives of ketones or esters tethered by a hydrocarbon or ether linkage to the 3-position of a pyridine ring undergo dearomatising nucleophilic attack on the ring once it is activated (as an acylpyridinium species) by the addition of methyl chloroformate. The bicyclic dihydropyridine products are in some cases unstable, but may be isolated after hydrogenation as fused b...

Amlodipine and lacidipine, conventional antihypertensive drugs, inhibited Leishmania donovani infection in vitro and in BALB/c mice when administered orally. These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites.

in this study, oxidation of some 3,5-diacyl or 3,5-diester 1,4-dihydropyridines to corresponding pyridine derivatives using sodium bromate in the presence of nh4cl, nahso4 and bu4nhso4 under thermal conditions has been investigated. the yield and structure of formed products is similar under all conditions; however, the reaction is accelerated in the presence of bu4nhso4 and nahso4. in addition...