نتایج جستجو برای: 14 dihydropyridine

تعداد نتایج: 361442  

14

Journal: :ادبیات پایداری 0

0

2003
DAVID T. YUE

We investigated the mechanism whereby ions cross dihydropyridinesensitive (L-type) Ca channels in guinea pig ventricular myocytes. At the singlechannel level, we found no evidence o f an anomalous mole-fraction effect like that reported previously for whole-cell currents in mixtures o f Ba and Ca. With the total concentration o f Ba + Ca kept constant at 10 (or 110) mM, neither conductance nor ...

Journal: :Journal of neuroimmunology 2009
Takahiro Maruta Hiroaki Yoshikawa Shuichi Fukasawa Sho Umeshita Yoshihiro Inaoka Shigeki Edahiro Hirotsugu Kado Yuko Motozaki Kazuo Iwasa Masahito Yamada

To investigate autoantibodies related to excitation-contraction (E-C) coupling in patients with myasthenia gravis (MG), we developed a novel method to detect autoantibodies against dihydropyridine receptor (DHPR). Using this method, we detected DHPR antibody in 37% (11 out of 30) of MG patients with thymoma. Antibodies were not detected in normal nor disease controls. The titer of DHPR antibodi...

Journal: :the iranian journal of pharmaceutical research 0
miyase gozde gunduz hacettepe university yeşim kaya hacettepe university rahime şimşek hacettepe university faculty of pharmacy dept.of pharmaceutical chemistry i̇nci şahin-erdemli hacettepe university cihat şafak hacettepe university

the present study reports a microwave-assisted method for the synthesis of twelve novel tricyclic 1,4-dihydropyridine derivatives in which dimethyl-substituted cyclohexane and / or tetrahydrothiophene rings are fused to the dhp ring. the structures of the compounds were confirmed by spectral methods and elemental analysis. the potassium channel opening effects of the compounds were determined o...

Journal: :Annals of the rheumatic diseases 2005
O Vignaux Y Allanore C Meune O Pascal D Duboc S Weber P Legmann A Kahan

BACKGROUND Primary myocardial involvement due to microcirculation impairment is common in systemic sclerosis (SSc). Cardiovascular magnetic resonance imaging (MRI) and tissue Doppler echocardiography (TDE) were recently shown to be more sensitive than conventional methods for the respective assessment of myocardial perfusion and contractility. Previous studies have suggested that dihydropyridin...

2005
O Vignaux

Background: Primary myocardial involvement due to microcirculation impairment is common in systemic sclerosis (SSc). Cardiovascular magnetic resonance imaging (MRI) and tissue Doppler echocardiography (TDE) were recently shown to be more sensitive than conventional methods for the respective assessment of myocardial perfusion and contractility. Previous studies have suggested that dihydropyridi...

Journal: :iranian journal of catalysis 2014
javad safaei-ghomi hossein shahbazi-alavi mohammad reza saberi-moghadam abolfazl ziarati

zrp2o7 nanoparticles (nps) as an efficient catalyst have been used for the preparation of 1,6-diamino-2- oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile derivatives via one-pot coupling of hyrazine hydrate, ethyl cyanoacetate, malononitrile and aromatic aldehydes under reflux conditions in ethanol. using this method we obtained low reaction times, easy isolation of the targeted molecules, e...

Journal: :Circulation research 1986
J B Habib C Bossaller S Wells C Williams J D Morrisett P D Henry

We tested the effects of low doses of a dihydropyridine calcium antagonist, PN 200110, on endothelium-dependent vascular relaxation in rabbits fed a 1% cholesterol diet. The drug was given orally, 1 mg/day, and control rabbits received placebo. Plasma total cholesterol after 10 weeks, was similar in the placebo- and PN 200110-treated groups. The respective values averaged 2140 +/- 116 (n = 14; ...

2010
Yumei Li

In the title compound, C(18)H(22)N(2)O(4), the dihedral angle between the two rings is 87.90 (6)°. The mean devation of the atoms in the dihydropyridine plane is 0.082 (3) Å. In the crystal, mol-ecules are linked by inter-molecular N-H⋯N hydrogen bonds, generating chains.

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