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تعداد نتایج: 753 فیلتر نتایج به سال:
BACKGROUND The objectives of this study were to evaluate the association between varicella-zoster virus (VZV)-specific humoral and cell-mediated immunity (CMI) to herpes zoster (HZ) and protection against HZ morbidity and to compare immune responses to HZ and zoster vaccine. METHODS In 981 elderly persons who developed HZ during a zoster vaccine efficacy trial (321 vaccinees and 660 placebo r...
Over the past ten years, a sub® eld of GIScience has been recognized that addresses the linkage between human thought regarding geographical space, and the mechanisms for implementing these concepts in computational models. This research areahas developed an identity through a series of successful international conferences and the establishment of a journal. It has also been complemented throug...
This study investigated the influence of genes and environment on the variation of apolipoprotein and lipid levels, which are important intermediate phenotypes in the pathways toward cardiovascular disease. Heritability estimates are presented, including those for apolipoprotein E and AII levels which have rarely been reported before. We studied twin samples from the Netherlands (two cohorts; n...
Objective To examine the practice of concealing drugs in patients’ foodstuff in nursing homes. Design Cross sectional study with data collected by structured interview. Setting All five health regions in Norway. Participants Professional carers of 1362 patients in 160 regular nursing home units and 564 patients in 90 special care units for people with dementia. Main outcome measures Frequency o...
Background. Attention-deficit hyperactivity disorder (ADHD) is the most commonly diagnosed behavioral problem in children. Global variations in diagnostic criteria and rating scales of ADHD either by DSM-IV or ICD 10 may contribute to variations in its prevalence. Objectives. The study was conducted to estimate the prevalence of ADHD and to determine its risk factors. Methodology. A cross-secti...
BACKGROUND The patient acceptable symptom state (PASS) is the value beyond which patients can consider themselves well. This concept can help in interpreting results of clinical trials. OBJECTIVE To determine the PASS estimate for patients with knee and hip osteoarthritis (OA) by assessing pain, patient's global assessment of disease activity, and functional impairment. METHODS A 4 week pro...
STUDY OBJECTIVE The aim was to explore whether maternal consumption of seafood is a determinant of birth weight in a dose dependent manner. DESIGN A population based survey of lifestyle factors in pregnancy was linked with information from antenatal and obstetric records. SETTING AND PARTICIPANTS Seventy five per cent of all 1362 women who delivered in the Faroe Islands during the study per...
BACKGROUND Previous studies have suggested that there may be long-term harm associated with postoperative complications. Uncertainty exists however, because of the need for risk adjustment and inconsistent definitions of postoperative morbidity. METHODS We did a longitudinal observational cohort study of patients undergoing major surgery. Case-mix adjustment was applied and morbidity was reco...
Linear stability analysis is inadequate for integrators designed for nondissipative systems such as Hamiltonian systems in which nonlinear effects are often decisive. Mathematical theory exists (KAM theory) for rigorous analysis of small perturbations from equilibria, but it needs to be expressed in a form that is more easily applicable to the study of area-preserving maps. We have pursued this...
Addiction is a complex psychiatric disorder considered to be a disease of the brain's natural reward reinforcement system. Repeated stimulation of the 'reward' pathway leads to adaptive changes in gene expression and synaptic organization that reinforce drug taking and underlie long-term changes in behaviour. The primitive nature of reward reinforcement pathways and the near universal ability o...
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