A 35-year-old woman presenting with abdominal pain was found to have mildly elevated catecholamine levels and a retroperitoneal mass. The patient underwent a negative I-123 MIBG scintigraphy scan and a nondiagnostic fine needle aspiration. Eleven years later the patient presented with a hypertensive emergency and markedly elevated catecholamine levels. A subsequent I-123 MIBG scintigraphy scan ...

Subjects Individual datasets from 6 prospective MIBG cohort studies performed in Japan between 1990 and 2009 were combined to make a pooled database of 1,322 chronic HF patients, as previously reported.4 Patients with HF from 6 Japanese medical institutions provided data for this study. All patients were enrolled in prospective observational studies, in which MIBG was approved for clinical use ...

PURPOSE To evaluate the potential utility of (123)I-metaiodobenzylguanine ((123)I-MIBG) scintigraphy and (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) for the detection of primary and metastatic lesions in pediatric neuroblastoma (NBL) patients, and to determine whether (18)F-FDG PET is as beneficial as (123)I-MIBG imaging. METHODS We selected 8 NBL patients with sig...

Signs or symptoms of impaired autonomic regulation of circulation are typically present in patients affected by Parkinson's disease (PD), in agreement with the cardiac sympathetic denervation discovered by Goldstein more than 15 yrs. ago. In particular, the majority of PD patients have a diffuse left ventricular myocardial sympathetic denervation, being a normal neurological condition present o...

P 2121 Myocardial 123I-metaiodobenzylguanidine (MIBG) Scintigraphy for the assessment of cardiac sympathetic nervous dysfunction in diabetic patients J. Nunomura, O. Uehara, M. Baba, M. Matsunaga Department of Neurology, Municipal Kuroishi Hospital, Kuroishi, Aomori, JAPAN, Department of Internal Medicine, Municipal Kuroishi Hospital, Kuroishi, Aomori, JAPAN, Department of Neurology, Hirosaki U...

A17-year-old woman had paroxysmal hypertension. Very high levels of urinary catecholamines suggested a diagnosis of pheochromocytoma (urinary norepinephrine 27 600 nmol/24 hours, normal ,485 nmol/24 hours; urinary normetanephrine 37 607 nmol/24 hours, normal ,2000 nmol/24 hours), but no adrenal tumor was found on the abdominal CT scan. Metaiodobenzylguanidine (MIBG) whole-body scintigraphy was ...

BACKGROUND Cerebral microbleeds (MBs) have been well investigated in Alzheimer's disease (AD), but not very extensively in non-AD dementias or in dementia with Lewy bodies (DLB). AIMS To elucidate the clinical significance of MBs in DLB. METHODS We compared the prevalence, locations and risk factors for MBs in 59 DLB and 81 AD patients. We visually counted MBs in each of the cortical and su...

OBJECTIVES We sought to evaluate the effects of angiotensin receptor blocker (ARB) on cardiac sympathetic nerve activity (CSNA) in patients with congestive heart failure (CHF) with a preserved left ventricular ejection fraction (LVEF). BACKGROUND Approximately 50% of patients with CHF have preserved LVEF. It is reported that ARB therapy improves CSNA in CHF patients and reduced LVEF. However,...

OBJECTIVE Complete allograft denervation occurs during heart transplantation. Partial ventricular sympathetic reinnervation may develop one year or later after transplantation and can be measured with iodine-123-meta-iodobenziylguanidine (MIBG) uptake. Aim of this study was to assess sinus node sympathetic reinnervation measured with heart rate variability and ventricular sympathetic reinnervat...