P 2121 Myocardial 123I-metaiodobenzylguanidine (MIBG) Scintigraphy for the assessment of cardiac sympathetic nervous dysfunction in diabetic patients J. Nunomura, O. Uehara, M. Baba, M. Matsunaga Department of Neurology, Municipal Kuroishi Hospital, Kuroishi, Aomori, JAPAN, Department of Internal Medicine, Municipal Kuroishi Hospital, Kuroishi, Aomori, JAPAN, Department of Neurology, Hirosaki U...

The crystal and molecular structures of five succinimidyl halobenzoates are reported. Corresponding derivatives with the respective halo-radionuclide (18F, 76Br, 123I/124I/125I/131I) were prepared and used for the radiolabeling of biologically active (macro-)molecules (peptides, proteins, antibodies) under mild labeling conditions. All compounds were crystalized from petroleum ether/ethyl aceta...

BACKGROUND The association of autonomic activation, left ventricular ejection fraction (LVEF) and heart failure functional class is poorly understood. OBJECTIVE Our aim was to correlate symptom severity with cardiac sympathetic activity, through iodine-123-metaiodobenzylguanidine (123I-MIBG) scintigraphy and with LVEF in systolic heart failure (HF) patients without previous beta-blocker treat...

Adrenal incidentalomas are defined as asymptomatic adrenal masses occasionally discovered during high-resolution imaging procedures such as computed tomography (CT) or magnetic resonance (MR). Pheochromocytoma, a potentially lethal chromaffin tumour, must be excluded before any invasive diagnostic procedures to avoid massive catecholamines release. Chromogranin A (CgA) is a member of the granin...

The neurotoxic potential of amphetamine and related drugs is well documented. However, methylphenidate, an amphetamine derivative used in the treatment of attention deficit hyperactivity disorder, and known to increase synaptic dopamine (DA) levels, seems to lack neurotoxic potential. It is hypothesized that both dopaminergic and serotonergic systems are involved in the neurotoxicity of ampheta...

OBJECTIVES The aim of this study was to examine the effects of essential hypertension on cardiac autonomic function in type 2 diabetic patients. BACKGROUND Hypertension is common in type 2 diabetic patients and is associated with a high mortality. However, the combined effects of type 2 diabetes and essential hypertension on cardiac autonomic function have not been fully elucidated. METHODS...

Retinis pigmentosa is a form of retinal dystrophy characterized by pigment deposition resulting in loss peripheral vision, tunnel night blindness and some cases full blindness. Parkinson’s disease progressive extrapyramidal neurological disorder rigidity, bradykinesia tremor at rest due to substantia nigra’s dopaminergic cell; this can be evaluated with 123I-ioflupane single-photon emission com...

Human Persistent Atrial Fibrillation Is Maintained by Rotors: The Jury Is Still Out Tomos E. Walters, MBBS; Jonathan M. Kalman, MBBS, PhD · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · 517 123I-Meta-Iodobenzylguanidine Guanidine–Guided Ventricular Tachycardia Ablation: Will Expanding the Target Improve the Aim? Niti R. Aggarwal, MD; Panithaya Chareonthaitawee,...

123I-iomazenilは「外科的治療が考慮される部分てんかん患者におけるてんかん焦点の診断」のための SPECT 用トレーサとして開発された．本トレーサは，脳における神経受容体の中でも大脳半球に豊富に存在する中枢性ベンゾジアゼピン受容体に結合する．この結合メカニズムをもとに当施設では，脳血管障害に対する臨床応用を検討してきた．第一に，123I-iomazenil投与後早期および後期の画像は，それぞれ脳血流量および脳代謝量分布を表す．よって，後期画像を早期画像で割った画像は PET 上の脳酸素摂取率分布を示す．この画像は，頚動脈内膜剝離術後過灌流の出現を予知できる．次に，123I-iomazenil投与後後期画像は，不可逆的な認知機能低下あるいは神経学的脱落症状を示す．一方で，後期画像のトレーサ集積低下は可逆的なこともあり，血行再建術後のトレーサ集積の回復は，術後認知機能改善ある...

We evaluated the clinical usefulness of the combined use of I-ioflupane brain single photon emission computed tomography (SPECT) and I-metaiodobenzylguanidine (MIBG) cardiac scintigraphy in discriminating uncertain parkinsonism with vascular lesions in striatal nuclei at magnetic resonance imaging (MRI). Forty-three consecutive patients with uncertain parkinsonism and vascular lesions at MRI in...