RNA-protein cross-links were introduced into E. coli 30S ribosomal subunits by treatment with methyl p-azidopEenyl acetimidate. After partial nuclease digestion of the RNA moiety, a number of cross-linked RNA-protein complexes were isolated by a new three-step procedure. Protein and RNA analysis of the individual complexes gave the following results: Proteins S3, S4, S5 and S8 are cross-linked ...

1. Littleton J. Receptor regulation as a unitary mechanism for drug tolerance and physical dependence – not quite as simple as it seemed! Addiction 2001;96:87‐101. 2. Hatsukami DK, Severson HH. Oral spit tobacco: Addiction, prevention and treatment. Nicotine Tob Res 1999;1:21‐4. 3. Tomar SL, Henningfield JE. Review of the evidence that pH is a determinant of nicotine dosage from oral use of smo...

This paper gives an overview of measures commonly used in reconviction studies and outlines how to use Police National Computer [PNC] data to conduct a reconviction study. It highlights the need for standardisation in how reconviction studies are conducted and openess about limitations of working with official sources of data. The paper is written for researchers, practitioners and students ali...

Considerable evidence suggests that "the lower the better" is a reasonable approach for reducing cardiovascular risk by lowering LDL cholesterol levels. Despite the reduction in cardiovascular events and mortality achieved by statin therapy, significant residual risk remains, especially in severe hereditary hypercholesterolemia, such as familial hypercholesterolemia. Some new strategies to achi...

This letter will take an example from the Japanese local telecommunications industry in the 1990s and analyze the cost structures of a basic service and an advanced service, focusing on the economies of scale and scope. Here, the basic service is defined as the plain old telephone service (POTS) while the advanced service the leased circuit service. There are three points we will make: first, t...

The incidence of thrombotic microangiopathy (TMA) was retrospectively evaluated in a cohort of 1223 patients with acquired immunodeficiency syndrome (AIDS) who were observed from January 1985 through December 1996 (before the era of highly active antiretroviral therapy [HAART]), and the incidence was prospectively assessed for 347 patients with AIDS during the period of January 1997 through Dec...