inhibitor of Mcl-1. Stewart et al. screened a library of stapled peptides based on the BH3 domains of BCL-2 family proteins (library depicted on left) and identified a selective inhibitor of MCL-1 (structure of the inhibitor in complex with Mcl-1 shown on the right), one of the anti-apoptotic family members that plays a key role in the survival of cancer cells. The peptide inhibitor, derived fr...

Background: The coronavirus disease 2019 (COVID-19) has rapidly spread worldwide, leading to increased concerns about long-term patients’ neuropsychiatric morbidity. Currently, there is still few data regarding mental health after hospital discharge of severe COVID-19 elderly patients. Considering this, the present study aims characterize morbidity in old Methods: In context an ongoing multidis...

the activity concentrations of 226ra, 232th, 40k and 137cs in water and sediment samples from hot springs of mahallat and  soil samples from their neighboring environs  have been determined using two high resolution high purity germanium (hpge) detectors with relative efficiencies 38.5% and 55%. the activity concentrations of 226ra, 232th, 40k and 137cs in sediment samples from hot spring donbe...

background: activity concentrations of 40k, 226ra and 228ra were measured in some sachet drinking water samples produced in nigeria. materials and methods: the measurement was done by using high-purity germanium (hpge) detector (canberra industries inc.). the measured activity concentrations for 226ra (u-series) and 228ra (thseries) were used with their ingested dose conversion factors to estim...

The fluorescence rise kinetics in saturating light display two well separated com ponents with largely different properties. The rapid rise from F„ to a first intermediate level, I ,, is photochemically controlled, while the following phases leading to a secondary intermediate level, I2, and to a peak level, P , are limited by thermal reactions. Treatm ents which primarily affect components at ...