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Background-—Depression is prevalent in coronary heart disease (CHD) patients and increases risk for acute coronary syndrome (ACS) recurrence and mortality despite optimal medical care. The pathways underlying this risk remain elusive. Psychological stress (PS) can provoke impairment in myocardial perfusion and trigger ACS. A confluence of acute PS with depression might reveal coronary vascular ...
A trial fibrillation (AF) is the most common cardiac arrhythmia, and those afflicted have reduced quality of life, functional status, and cardiac performance. Patients with AF have a higher risk of stroke, heart failure, and premature death relative to patients without AF. It is estimated that 2.5% of the population worldwide has AF, and the prevalence of AF increases substantially with age, es...
Tissuemorphogenesis inplants requirescommunicationbetweencells, a process involving the trafficking ofmolecules through plasmodesmata (PD). PD conductivity is regulated by endogenous and exogenous signals. However, the underlying signaling mechanisms remain enigmatic. In Arabidopsis, signal transduction mediated by the receptor-like kinase STRUBBELIG (SUB) contributes to inter-cell layer signal...
1 Hospices Civils de Lyon, Hôpital Neurologique, Neurologie C; Université Lyon I, Faculté de Médecine et de Maı̈eutique Lyon Sud Charles Mérieux, Lyon, France 2 CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron, France 3 Movement Disorder Unit, Department of Psychiatry and Neurology, CHU de Grenoble, Joseph Fourier University, 38043 Grenoble, France and INSERM, Unite 836, Grenoble Institu...
To direct human embryonic stem (HES) cells to a dopaminergic neuronal fate, we cocultured HES cells that were exposed to both sonic hedgehog and fibroblast growth factor 8 with telomerase-immortalized human fetal midbrain astrocytes. These astrocytes substantially potentiated dopaminergic neurogenesis by both WA09 and WA01 HES cells, biasing them to the A9 nigrostriatal phenotype. When transpla...
Correspondence to Ira Tabas: [email protected] Abbreviations used in this paper: apoB, apolipoprotein B; CHOP, C/EB-homologous protein; DAMP, damage-associated molecular pattern; LP, lipoprotein; SMC, smooth muscle cell. Atherosclerotic vascular disease is the underlying cause of myocardial infarction (heart attack), stroke, unstable angina (ischemic heart pain), and sudden cardiac death (Lusis...
Correspondence to Markus Babst: [email protected] Abbreviations used in this paper: ART, arrestin-related trafficking adaptor; ESCRT, endosomal sorting complex required for transport; GPCR, G protein–coupled receptor; ILV, intraluminal vesicle; LID, loop interaction domain; MVB, multivesicular body; QC, quality control. Protein degradation is crucial for proper cellular function. It can fi...
Alterations in nuclear shape and positioning are often associated with changes in the behavior of cells (Starr and Fridolfsson, 2010). Recent studies proposed that tissue stiffness affects the levels of the nuclear lamina protein lamin A/C, resulting in altered transcriptional regulation (Simon and Wilson, 2011; Burke and Stewart, 2013; Zwerger et al., 2013; Fedorchak et al., 2014; Swift and Di...
Correspondence to Kazutoshi Mori: [email protected] Y. Kamiya’s present address is Graduate School of Engineering and EcoTopia Science Institute, Nagoya University, Nagoya 464-8603, Japan. Abbreviations used in this paper: ERmanI, ER mannosidase I; gpERAD, ERassociated glycoprotein degradation; KO, knockout; M9, Man9GlcNAc2; M8B, Man8GlcNAc2 isomer B; M1,6E, 1,6-mannose exposed; ...
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