A culture supernatant of concanavalin A-activated spleen cells (Con A supernatant) induced murine macrophages to express Ia antigens in vitro. Biochemical characterization of the Con A supernatant indicated that the macrophage Ia antigen regulatory activity shares molecular weight, pI, and hydrophobic and affinity characteristics with immune interferon (IFN-gamma). Antiserum to mouse IFN-gamma ...

In a prior report we presented evidence that insulinlike growth factor-I (IGF-I) can act in an autocrine fashion by demonstrating that FRTL-5 cells transfected with hIGF-IA fusion genes express and secrete biologically active IGF-I that renders the stimulation of DNA synthesis in FRTL-5 cells independent of heir requirement for exogenous IGFs or insulin. To determine if IGF-1’s autocrine action...

Proton conductivity has been studied thoroughly in two isomeric In(III)-isophthalate based MOFs. In-IA-2D-1 is capable of showing proton conductivity (3.4 × 10(-3) S cm(-1)) under humidified conditions (98% RH), whereas In-IA-2D-2 can conduct protons (2.6 × 10(-5) S cm(-1)) under humidified as well as anhydrous conditions.

Bullacta exarata has been consumed in Asia, not only as a part of the normal diet, but also as a traditional Chinese medicine with liver- and kidney-benefitting functions. Several scientific investigations involving extraction of biomolecules from this mollusk and pharmacological studies on their biological activities have been carried out. However, little is known regarding the antitumor prope...

The HLA-A*24 allele has shown negative associations with autoantibodies to islet antigen-2 (IA-2) and zinc transporter 8 (ZnT8) in patients with established type 1 diabetes. Understanding how this HLA class I allele affects humoral islet autoimmunity gives new insights into disease pathogenesis. We therefore investigated the epitope specificity of associations between HLA-A*24 and islet autoant...

Let I be a set and let A, f be functions. The functor f↾IA yielding a many sorted function indexed by I is defined by: (Def. 1) For every set i such that i ∈ I holds (f↾IA)(i) = f↾A(i). One can prove the following propositions: (1) For every set I and for every many sorted set A indexed by I holds idUnionA↾IA = idA. (2) Let I be a set, A, B be many sorted sets indexed by I, and f , g be functio...

background: this double-blinded, randomized clinical trial was designed to evaluate the comparison of intravenous versus intraarticular (ia) administration of midazolam on postoperative pain after knee arthroscopy. materials and methods: in this study, 75 patients randomized in three groups to receive 75 mc/kg ia injection of midazolam and 10 ml intravenous injection of isotonic saline (group i...

Invasive aspergillosis (IA) are a major complication in immunocompromized patients where can be serious and rapidly fatal. Early diagnosis and early appropriate antifungal treatment is important in reducing mortality and morbidity. But despite many efforts to develop detection methods, the diagnosis of IA still remains challenging and current conventional methods are limited for adequate diagno...

We review the use of Type Ia supernovae for cosmological distance determinations. Low-redshift SNe Ia (z ∼ 0.1) demonstrate that the Hubble expansion is linear, that H0 = 65 ± 2 (statistical) km s −1 Mpc, and that the properties of dust in other galaxies are similar to those of dust in the Milky Way. We find that the light curves of high-redshift (z = 0.3–1) SNe Ia are stretched in a manner con...

Type Ia supernova (SNe Ia) are thought to originate in the explosion of a white dwarf 1. The explosion could be triggered by the merger of two white dwarfs 2,3