an indirect enzyme–linked immunosorbent assay (elisa) was developed for screening of antibody to avian infectious bronchitis virus (ibv). antigen was prepared from whole-purified ibv massachusetts serotype (br 801 strain). optimum dilution with minimum background for antigen concentration, rabbit anti-chicken conjugate and sera in developed elisa was determined 0.1μg/ml, 1:3000 and 1:100, respe...

Studies suggest certain stimuli like apoptosis behind the aberrant expression of circulating specific auto-antibodies in Type-1 diabetic patients. In present study, we investigated whether Streptozotocin (a diabetogenic compound) induced Rat RINm5f Insulinoma cells can expose immunogenic cryptic antigens. A time course treatment with 4 mM revealed 6hrs as minimal period to induce without much e...

Abstract Antigen-specific CD8 T cells gradually have impaired functions in chronic infection and cancers, which is termed cell exhaustion. Since exhaustion associated with programmed death 1 (PD-1), the blockade of PD-1 pathway reinvigorates exhausted cells, resulting better control cancers. Stem-like are important for maintenance antigen-specific during cancers because they self-renewal abilit...

background: meningioma is among the most common slow growing central nervous neoplasms, which recurs locally despite the benign histologic features. the aim of this study was to evaluate osteopontin and ki67 expressions in different histologic grades of meningioma in a group of iranian people. methods: in this cross-sectional study, first, the paraffin blocks with the definite pathological diag...

background: the aim of this study was to assess the performance of antigen b (agb) isolated from different echinococcus granulosus intermediate hosts and from different cyst locations for immu­nodiagnosis of human cystic echinococcosis (ce). methods: hydatid cyst fluids were collected from lung and liver cysts of sheep, liver cysts of goats, lung cysts of camels and cattle, and liver cysts of h...