We hypothesized that anesthetic dose of riluzole, an inhibitor of glutamate neurotransmission, may affect the activity and/or expression of neuronal NOS (nNOS). Riluzole, N(G)-nitro-L-arginine-methyl ester (L-NAME) and 7-nitro indazole (7-NI) produced a concentration-related inhibition of nNOS activity in vitro. Riluzole competed with 7-NI for inhibition of nNOS activity, but had no effect on n...

Disastrous effect of nickel on spinach was discussed by number of authors but the effect of amendments like biochar with nickel on Spinacea oleraceaL. is not still discussed by any author of the world because biochar was used as soil amendments which play a vital role in reducing mobilization and uptake of nickel by spinach plants.  As nickel contaminated plants are very harmful for th...

This research was conducted with a view to determine the risks associated Cu, and Ni through consumption of spices viz; curry leaves, ginger, turmeric, garlic cloves) sold within Kaduna Metropolis. The samples were analyzed for Cu using Atomic Absorption Spectrophotometer (AAS). mean concentrations metals in are leaves: - (0.123 mg/kg); (0.029 mg/kg). Ginger:- (0.063 (0.046 Garlic: (0.064 (0.03...

(1) Aim of the Study: In this study, we aimed to evaluate vascular damage and effects nitric oxide synthase (NOS) enzyme inhibitors in hepatic caused by high doses acetaminophen (APAP). (2) Material methods: Fifty-three Swiss albino male mice were used for study. Hepatic thoracic aorta toxicity 2 or 6 h exposures APAP (300 mg/kg intraperitoneally (i.p.)) evaluated. The general NOS inhibitor NG-...

This study aims at determining the elemental concentrations of Cu, Zn, Cr, Pb, Ni, Co and Cd in the sediment samples from Odo-Owa and Yemoji streams in Ijebu-Ode Local Government Area (L.G.A), South Western (SW) Nigeria, using Atomic Absorption Spectrophotometer and comparing the concentration of these metals in the two streams with other studies and with acceptable concentration values for met...

Previously, we have reported that intranigral infusions of malonate, an inhibitor of mitochondrial function, lead to the degeneration of the dopaminergic neurons of the nigrostriatal pathway that is mediated, at least in part, through NMDA receptor activation and nitric oxide formation. In the present study, unilateral focal infusions of malonate into the nucleus basalis magnocellularis (nbM) o...