dihydropyridines (dhps) with carboxamides in the 3 and 5 positions show anti-tuberculosis activity. the purpose of the present study was to synthesize new dhps that would possibly possess anti-tuberculosis activity. so a series of n-aryl-1,4-dihydropyridine-3,5-dicarboxamides (3-38) was prepared. they were screened as antitubercular agents against one type of fast growing mycobacterium (m. smeg...

The palladium-assisted one-pot three-component reactions of aldehydes, amines and olefins proceeded smoothly to give 2,6-unsubstituted 1,4-dihydropyridines (1,4-DHPs) using molecular oxygen as a sole oxidant. It also provides efficient Pd-catalyzed aerobic oxidation access to the anti-Markovnikov oxidative amination products of olefins from primary aromatic amines and alkenes. The method is ato...