The hepatotoxic bile acid glycochenodeoxycholate (GCDC) modulates hepatocyte cell death through activation of JNK, Akt, and Erk. The nonhepatotoxic bile acid taurocholate activates Akt and Erk through the sphingosine-1-phosphate receptor 2 (S1PR2). The role of the S1PR2 in GCDC-mediated apoptosis and kinase activation is unknown. Studies were done in rat hepatocytes, HUH7 cells, and HUH7 cells ...

Abstract Inflammation is a body’s defense response for short duration however if persists long periods, it causes tissue damage and pathological consequences. Moreover, paves the way several diseases including inflammatory bowel disease (IBD). Therefore, there an urgent need natural safe anti-inflammatory therapeutic compound. To address this issue, we aimed to determine effects of DJ-X-013, us...

Fifteen strawberry germplasm collected from local and exotic sources were evaluated for different qualitative and quantitative characters. The germplasm showed variation for majority of the studied traits. Plant height during peak harvest ranged from 14.67 to 25.00 cm and FA 007 exhibited the tallest plants. The maximum number of leaves plant was produced by FA 006 (46.67). The maximum number o...

In the conditions of reforming primary education organization local history work in New Ukrainian school and preparation students pedagogical colleges for it acquire special urgency. As is evidenced by our analysis situation with studies at 38 Ukraine, carried out mainly specialty 013 Primary Education three areas: during practice, course educational students, while organizing scientific studen...