Sphingosine kinase isoform 1 (SK1) inhibitors may serve as therapeutic agents for proliferative diseases, including hypertension. We synthesized a series of sphingosine-based SK1-selective inhibitors, the most potent of which is RB-005 (IC(50) = 3.6 μM), which also induced proteasomal degradation of SK1 in human pulmonary arterial smooth muscle cells.

Amid all the complications of dealing with globalization and childhood, including its great unevenness, a crucial issue involves its relationship to larger, or at least earlier, processes of change. No conclusion can hope to embrace the various findings of the essays in this collection, but a final comment on this relationship will help. The fundamental transformation of modern childhood began ...

interface language could be developed for other languages such as Verilog or even a Larch-based speciication. A parser would be developed that translates the VSPEC interface for each of these languages into a general abstract syntax tree. Constraint checking and other analysis could be performed on the general AST independent of the original language of the speciication. Tools to synthesize des...

the numbers of nodes of the original and optimized circuits after being cleaned up by SIS command " sweep " and then decomposed into AND/OR gates. (2) # FFs (orig. / opt.): the numbers of flip-flops in the original and optimized circuits. For instance, s13207 has 490 flip-flops, but only 453 left in the optimized circuit. (3) # equiv. internal pairs (comb / seq): the number of internal signal p...