•Access to a wide range of linear alcohols and arylated alkanes•Compatible with aliphatic electronically deactivated epoxides•No pre-activation required for primary alcohols•Hexafluoroisopropanol is key the reactivity Substitution reactions are common way couple two molecular fragments at sp3-hybridized carbon atom. The one or both coupling partners typically required, which adds additional che...

The ability to move across the landscape is a fundamental property of species that can determine their chances persistence in fragmented landscapes and rapidly changing environments. Despite its importance, empirical evidence showing effect movement capacity on patterns limited. In this study, we examine role flight efficiency likelihood crossing man-made habitat gap. We used data from Biologic...

Inactivation of the tumor suppressor gene j6Th (4 is the most common genetic alteration in human head and neck squamous cell cancer (HNSCC), making it an ideal target for gene replacement. We constructed a replicationdefective, recombinant adenovirus capable of directing a high level of J6INK4A protein expression (AdS-p16) to investigate its benefit in treating HNSCC. Initial in vitro experimen...

Prior to the onset of the cardinal motor features of idiop athic Parkinson‘s disease (PD), other manifestations of neurodegeneration such as olfactory dysfunction are often apparent. Characterizing these potential biomarkers of preclinical PD is particularly important in identifying individuals who will go on to develop disabling symptoms, and thus be good candidates for new neuroprotective str...

Genome size estimates and chromosome number information can be useful for studying the evolution or taxonomy of a group and also can be useful for plant breeders in predicting cross-compatibility. Callicarpa L. is a group of ’140 species with nearly worldwide distribution. There are no estimates of genome size in the literature and the information on chromosome numbers is limited. Genome size e...

One of the very first digital library developments was the transition of bibliographies and other reference works to digital formats and the rise of online services which allowed new kinds of remote searching. But, somehow, the reference collection as a library service has not transferred effectively into the digital library environment. How might we re-design the functionality of the reference...