As the number of patients waiting to receive transplants increases, there is a need to explore all possible donation opportunities. In this case report, we describe the transplantation of a liver from a donor who died after ethylene glycol poisoning into a woman with alcoholic liver disease with cirrhosis and associated ascites. Donor management, including ethanol, fomepizol and haemodialysis, ...

The discovery that ethylene glycol monomethyl ether (EGME) could affect the testis and the developing fetus in laboratory animals prompted further work to understand the effect of EGME and to examine additional glycol ethers to see if they showed EGME's reprotoxicity. Propylene glycol monomethyl ether (PGME) was shown not to cause testicular atrophy or to affect the development of rats at 600 p...

Ethylene glycol, a common antifreeze, coolant and industrial solvent, is responsible for many instances of accidental and intentional poisoning annually. Following ingestion, ethylene glycol is first hepatically metabolised to glycoaldehyde by alcohol dehydrogenase. Glycoaldehyde is then oxidised to glycolic acid, glyoxylic acid and finally oxalic acid. While ethylene glycol itself causes intox...

This discussion will highlight the following 9 specific points that related to metabolic acidosis caused by various toxins. The current recommendation suggests that alcohol dehydrogenase inhibitor fomepizole is preferred to ethanol in treatment of methanol and ethylene glycol poisoning, but analysis of the enzyme kinetics indicates that ethanol is a better alternative. In the presence of a mode...

SYNTHESIS 2006, No. 4, pp 0645–0653xx.xx.2006 Advanced online publication: 25.01.2006 DOI: 10.1055/s-2006-926313; Art ID: M05505SS © Georg Thieme Verlag Stuttgart · New York Abstract: Starting from glycidol, the synthesis of dimethoxytritylated glycol nucleoside phosphoramidites of adenine (A), thymine (T), uracil (U), guanine (G), and cytosine (C) is reported. These phosphoramidites are the bu...

creams used for atopic eczema in Birmingham, UK illegally contain potent corticosteroids. Arch Dis Child 2003;88:1056–7. 15 Geiling EMK, Cannon PR. Pathological effects of elixir of sulphanilamide (diethylene glycol) poisoning. JAMA 1938;111:919–26. 16 Okuonghae HO, Ighogboja IS, Lawson JO, et al. Diethylene glycol poisoning in Nigerian children. Ann Trop Paediatr 1992;12:235–8. 17 Hanif M, Mob...

THE USE of polyethylene glycol (PEG) in preservation solutions has been associated with a decreased incidence of rejection in clinical and experimental transplantation. Using the isolated perfused rat liver model, we found that PEG, when added to phosphate-buffered sucrose solution (PBSL), provided improved liver preservation. A direct comparison of three different molecular configurations of P...

patient developed occupational dermatitis from butylene glycol in a soap (9, 10). 2 large-scale group studies, including 364 and 272 patients, give frequencies of contact allergy to 1,3-butylene glycol of 0.4% and 1.1%, respectively, of patients tested (1, 2). Although 1,3-butylene glycol has been considered a safe cosmetic ingredient and a rare contact allergen, we suggest that allergy to it w...