“[µ3-2، 5-dioxyocyclohexylidene) -bis ((2-hydrido) -nonacarbonyl-triruthenium]” الدراسات الطوبولوجية لـمركب باستخدام نظرية QTAIM (نظرية الكم للذرات في الجزيئات) تم تشخيص المركب ضمن مستوى DFT حيث تتفق المتغيرات المقدرة مع السابقة للمعقدات المعدنية الانتقالية المماثلة أظهرت الدراسة لمكون الجسر الأساسي Ru3H2 وجود النقاط الحرجة للرابطة بين الذرات Ru(1), Ru(2),Ru(3) ونتيجة لتلك حساب مؤشر عدم التمركز...

PURPOSE To investigate the effect of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2-E) on degradative functions of lysosomes in human retinal pigment epithelial (RPE) cells and to evaluate its mechanism of action. METHODS A2-E was coupled to low-density lipoprotein (LDL). Human RPE cell cultures were loaded with the A2-E/LDL complex, and controls were run with medium contai...

BACKGROUND Development of resistance to therapy continues to be a serious clinical problem in lung cancer management. We previously identified that Annexin A2 is significantly up-regulated in cisplatin-resistant non-small cell lung cancer (NSCLC) A549/DDP cells. However, the exact function and molecular mechanism of Annexin A2 in cisplatin resistance of NSCLCs has not been determined. METHODS...

1.16. Again, I’ll only do the triangle inequality. Let x = (a1, . . . , an), y = (b1, . . . , bn), z = (c1, . . . , cn) be three points in Rn, then there is some integer j, 1 ≤ j ≤ n where the max occurs, so that d∞(x, y) = |aj − bj |. Hence, d∞(x, y) = |(aj−cj)+(cj−bj)| ≤ |aj−cj |+|cj−bj | But, |aj−cj | ≤ max{|a1− c1|, . . . , |an − cn|} = d∞(x, z), since it is one of the terms occurring in th...

In the human fetal lung, surfactant protein A (SP-A) is encoded by two highly similar genes, SP-A1 and SP-A2, which are developmentally and hormonally regulated. Using primer extension analysis, we evaluated the levels of SP-A1 and SP-A2 mRNA transcripts in human fetal lung explants and in a human adult lung adenocarcinoma cell line (H441 cells) cultured in the absence or presence of either dib...

To investigate how T cells recognize allogeneic class I proteins encoded by the major histocompatibility complex (MHC), we examined the human cytotoxic T lymphocytes (CTL) elicited in a mixed lymphocyte reaction against a lymphoblastoid B-cell line (JY) whose MHC-class I proteins are HLA-A2 and -B7. By panning the responding T cells on plates that were coated with purified HLA-A2, an essentiall...

Several antigens have been tested as vaccine candidates against Leishmania infections but controversial results have been reported when different antigens are co-administered in combined vaccination protocols. Immunization with A2 or nucleoside hydrolase (NH) antigens was previously shown to induce Th1 immune responses and protection in BALB/c mice against Leishmania donovani and L. amazonensis...

Factor VIIIa, the protein cofactor for factor IXa, is comprised of A1, A2, and A3-C1-C2 subunits. Recently, we showed that isolated A2 subunit enhanced the kcat for factor IXa-catalyzed activation of factor X by approximately 100-fold ( approximately 1 min-1), whereas isolated A1 or A3-C1-C2 subunits showed no effect on this rate (Fay, P. J., and Koshibu, K. J. (1998) J. Biol. Chem. 273, 19049-...

Fluorescence resonance energy transfer between cyan fluorescent protein- and yellow fluorescent protein-tagged MHC class I molecules reports on their spatial organization during assembly and export from the endoplasmic reticulum (ER). A fraction of MHC class I molecules is clustered in the ER at steady state. Contrary to expectations from biochemical models, this fraction is not bound to the TA...