CLIP-170 belongs to a group of proteins (+TIPs) with the enigmatic ability to dynamically track growing microtubule plus-ends. CLIP-170 regulates microtubule dynamics in vivo and has been implicated in cargo-microtubule interactions in vivo and in vitro. Though plus-end tracking likely has intimate connections to +TIP function, little is known about the mechanism(s) by which this dynamic locali...

The cytoplasmic linker protein (CLIP)-170, an outer kinetochore protein, has a role in kinetochore-microtubule attachment and chromosome alignment during mitosis. However, the mechanism by which CLIP-170 is involved in chromosome alignment is not known. Here, we show that CLIP-170 colocalizes with Polo-like kinase 1 (PLK1) at kinetochores during early mitosis. Depletion of CLIP-170 results in a...

Cytoplasmic linker protein 170 (CLIP-170) is a prototype of the plus end-tracking proteins that regulate microtubule dynamics, but it is obscure how CLIP-170 recognizes the microtubule plus end and contributes to polymerization rescue. Crystallographic, NMR, and mutation studies of two tandem cytoskeleton-associated protein glycine-rich (CAP-Gly) domains of CLIP-170, CAP-Gly-1 and CAP-Gly-2, re...

http://bmj.com/cgi/content/full/329/7458/170 Updated information and services can be found at: These include: References http://bmj.com/cgi/content/full/329/7458/170#BIBL This article cites 4 articles, 1 of which can be accessed free at: Rapid responses http://bmj.com/cgi/eletter-submit/329/7458/170 You can respond to this article at: http://bmj.com/cgi/content/full/329/7458/170#responses free ...

INTRODUCTION ........................................ 169 HISTORY ........................................ 170 CLASSIFICATION AND NOMENCLATURE .................................. 170 PROPERTIES OF VIRUSES ......... .......................... 170 Isolations and serological relationships ................................... 170 Morphology ........................................ 171 Physical and ch...