STUDY OBJECTIVE To investigate the effects of preanesthetic oral clonidine on total propofol requirement for uniform minor surgery (breast conservative surgery: breast cancer removal with axillary lymph node dissection), and to compare the action of clonidine with that of preanesthetic oral diazepam, a commonly used benzodiazepine. DESIGN Randomized double-blinded study. SETTING Operating r...

BACKGROUND Preemptive analgesia is the blocking of pain perception afferent pathways before noxious painful stimuli. Clonidine is an alpha agonist drug that is partially selective for α-2 adrenoreceptors. Clonidine is used as anti-anxiety medication and an, analgesic, and it prolongs the duration of the block in the brachial plexus block. OBJECTIVES To compare the effect of preemptive clonidi...

Three studies were undertaken to reevaluate (1) whether there is a peripheral component in the reduction of sympathetic activity caused by centrally acting drugs; and (2) whether the antihypertensive effect of these drugs is due entirely to this reduction. Plasma growth hormone and norepinephrine concentrations were used as respective markers of central a-adrenoceptor stimulation and peripheral...

A partial recovery of locomotor functions has been shown in spinal cord-transected (Tx) cats after regular treadmill training and repeated administration of clonidine, an 2-adrenoreceptor agonist. However, clonidine has generally failed to show prolocomotor effects in other models (e.g., rat or mudpuppy in vitro-isolated spinal cord preparations). The reasons for this discrepancy remain unclear...

Background and Objectives: Epidural anesthesia is a popular technique for providing lower limb surgeries. Dexmedetomidine Clonidine are known to enhance the effect of local anaesthetics. The purpose this study was compare impact dexmedetomidine clonidine on onset duration epidural anaesthesia using bupivacaine. Methods: After IEC approval, prospective, randomized, double blinded conducted 60 AS...

The effect of intravenous clonidine on pentagastrin-induced gastric acid secretion has been studied in conscious dogs with Heidenhain pouches. Dose-dependent enhancement of secretion was found in response to clonidine (5-20 mu/kg). Clonidine (20 mug/kg) increased the maximal secretory rate to pentagastrin to a value not significantly different from the maximal response to histamine.

In an open, randomized, cross-over study the hypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone combinations were compared. The diastolic morning blood pressure could be reduced to 95 mm. Hg or below in significantly more patients with clonidine than with methyldopa. Side effects, however, were more commonly encountered during the clonidine than during...

In this study, three lines of evidence suggest a role for α(2)-adrenoreceptors in rat pup odor-preference learning: olfactory bulb infusions of the α(2)-antagonist, yohimbine, prevents learning; the α(2)-agonist, clonidine, paired with odor, induces learning; and subthreshold clonidine paired with subthreshold β-adrenoceptor activation also recruits learning. Increased mitral cell layer pCREB o...

BACKGROUND Clonidine was originally used to lower blood pressure. It acts on the central nervous system and may reduce withdrawal symptoms in various addictive behaviours, including tobacco use. OBJECTIVES The aim of this review is to determine clonidine's effectiveness in helping smokers to quit. SEARCH STRATEGY We searched the Cochrane Tobacco Addiction Group trials register for trials of...