نتایج جستجو برای: کاتیونهای tl
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BACKGROUND Leucocyte telomere length (TL) is a potential biomarker of ageing and risk for age-related disease. Leucocyte TL is heritable and shows substantial differences by race/ethnicity. Recent genome-wide association studies (GWAS) report ~10 loci harbouring SNPs associated with leucocyte TL, but these studies focus primarily on populations of European ancestry. OBJECTIVE This study aims ...
Specific binding of immunoliposomes to target tumor cells was investigated in a xenograft model (athymic nude mice) of i.p. growing human ovarian carcinoma (OVCAR-3). For the first time, quantitative evidence is presented that attachment of a tumor-specific antibody (OV-TL 3) dramatically enhances the association of liposomes with i.p. growing OVCAR-3 cells. The OV-TL 3-mediated binding of lipo...
Here we demonstrate that monovalent cations can localize around B-DNA in geometrically regular, sequence-specific sites in oligonucleotide crystals. Positions of monovalent ions were determined from high-resolution X-ray diffraction of DNA crystals grown in the presence of thallium(I) cations (Tl(+)). Tl(+) has previously been shown to be a useful K(+) mimic. Tl(+) positions determined by refin...
PURPOSE To compare various measures of training load (TL) derived from physiological (heart rate [HR]), perceptual (rating of perceived exertion [RPE]), and physical (global positioning system [GPS] and accelerometer) data during in-season field-based training for professional soccer. METHODS Fifteen professional male soccer players (age 24.9 ± 5.4 y, body mass 77.6 ± 7.5 kg, height 181.1 ± 6...
A Prospective Study of Leukocyte Telomere Length and Risk of Type 2 Diabetes in Postmenopausal Women
Telomere length (TL) has been implicated in the pathogenesis of age-related disorders. However, there are no prospective studies directly investigating the role of TL and relevant genes in diabetes development. In the multiethnic Women's Health Initiative, we identified 1,675 incident diabetes case participants in 6 years of follow-up and 2,382 control participants matched by age, ethnicity, cl...
Cys synthesis in plants takes place in plastids, cytosol, and mitochondria. Why Cys synthesis is required in all compartments with autonomous protein biosynthesis and whether Cys is exchanged between them has remained enigmatic. This question was addressed using Arabidopsis thaliana T-DNA insertion lines deficient in the final step of Cys biosynthesis catalyzed by the enzyme O-acetylserine(thio...
5 The Proof of Theorem 2.1. 27 5.1 Estimates for Tl,m, l ≥ 0, m < −l. . . . . . . . . . . . . . . . . . . . . . . . . . 29 5.2 Estimates for Tl,m, l ≥ 0, m > 0. . . . . . . . . . . . . . . . . . . . . . . . . . . 31 5.3 Estimates for Tl,m, l ≥ 0, −l ≤ m ≤ 0. . . . . . . . . . . . . . . . . . . . . . . . 33 5.4 Estimates for T (ε) l R −1 i0 , l ≥ 0. . . . . . . . . . . . . . . . . . . . . . . . ...
Triazole-linked morpholino ((TL)MO) oligonucleic acids were synthesised using the Cu(I) catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the (TL)MO modification gives higher Tm values than the corresponding (TL)DNA modification.
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