In order to study the interaction of genetic and hormonal factors during murine hepatocarcinogenesis, we compared the number of liver tumors induced by treatment of 12-day-old mice with N,N-diethylnitrosamine (DEN) (0.05 mumol/g body wt) in intact mice and animals gonadectomized at 8 weeks of age from the three inbred strains, C3H/HeJ (C3H), C57BL/6J (B6), and C57BR/cdJ (BR). At 50 weeks of age...

OBJECTIVE To investigate the effects of airway obstruction on albuterol-mediated variations in the resistive and elastic properties of the respiratory system of adult patients with asthma. METHODS This study comprised 24 healthy controls and 69 patients with asthma, all of whom were nonsmokers. The patients were divided into three groups according to the severity of airway obstruction (mild, ...

Heme oxygenase (HO), in conjunction with biliverdin reductase, degrades heme to carbon monoxide, ferrous iron and bilirubin (BR); the latter is a potent antioxidant. The induced isoform HO-1 has evoked intense research interest, especially because it manifests anti-inflammatory and anti-apoptotic effects relieving acute cell stress. The mechanisms by which HO mediates the described effects are ...

Background: In 2017, international consensus have redefined patients with borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC) according to three distinct dimensions: anatomical, biological, and conditional criteria. However, until now, there been few validation studies for this new The aim of study was validate the anatomical biological definitions BR-PDAC oncological outcomes in p...

In the title salt, C(5)H(7)Br(2)N(2) (+)·Br(-), the cation and anion are connected by an N-H⋯Br hydrogen bond. In the crystal, there are inter-calated layers parallel to (10-2) in which bromide ions are located between the cations. Weak inter-molecular C-H⋯Br hydrogen bonds are also observed.

In the title compound, (C(8)H(12)N)(2)[ZnBr(4)], the coordination geometry of the anion is approximately tetra-hedral. The Zn-Br bond lengths range from 2.3901 (19) to 2.449 (2) Å and the Br-Zn-Br angles range from 107.09 (8) to 112.48 (8)°. In the crystal, each [ZnBr(4)](2-) anion is connected to four cations through two N-H⋯Br and two C-H⋯Br hydrogen bonds, forming two-dimensional ⋯(cation)(2...

In the crystal structure of the title compound, C(9)H(11)N(2)O(4) (+)·Br(-), the ethanaminium cations and Br(-) anions are linked together by N-H⋯Br and O-H⋯Br hydrogen bonding. In the cation, the nitro group is twisted with respect to the benzene ring, making a dihedral angle of 21.43 (5)°.

The title compound, C18H25BrO, crystallized as a racemate with four independent mol-ecules in the asymmetric unit. In the crystal, three of these four mol-ecules are linked via C-Br⋯Br-C halogen bonds [Br⋯Br = 3.662 (2) and 3.652 (2) Å], forming dimers.

In plants, activation of growth and activation of immunity are opposing processes that define a trade-off. In the past few years, the growth-promoting hormones brassinosteroids (BR) have emerged as negative regulators of pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI), promoting growth at the expense of defense. The crosstalk between BR and PTI signaling was described as n...

In the crystal structure of the title compound, (C(7)H(10)N)(2)[ZnBr(4)], the coordination geometry of the anion is approximately tetra-hedral and a twofold rotation axis passes through the Zn atom. The Zn-Br bond lengths range from 2.400 (2) to 2.408 (3) Å and the Br-Zn-Br angles range from 108.14 (6) to 115.15 (15)°. In the crystal structure, the [ZnBr(4)](2-) anion is connected to two cation...