نتایج جستجو برای: ژن stat5b

تعداد نتایج: 16292  

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2013
Chunja Lee Xinxin Ding David S Riddick

3-Methylcholanthrene (MC) is a readily metabolized aryl hydrocarbon receptor (AHR) agonist. MC disrupts expression of mouse hepatic growth hormone (GH) signaling components and suppresses cytochrome P450 2D9 (Cyp2d9), a male-specific gene controlled by pulsatile GH via signal transducer and activator of transcription 5b (STAT5b). To determine if these effects of MC depend on hepatic microsomal ...

2017
Saisai Li Bo Sheng Menghuang Zhao Qi Shen Haiyan Zhu Xueqiong Zhu

Signal transducer and activator of transcription (STAT), a family of latent cytoplasmic transcription factors, are composed of seven identified members (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). STATs are associated with several biological processes such as cell proliferation, invasion, and metastasis in various cancer types. In addition, the STAT family has been well studied as a pro...

Journal: :Diabetes 2005
Katharina Laubner Timothy J Kieffer Ni T Lam Xinjie Niu Franz Jakob Jochen Seufert

Leptin inhibits insulin secretion and preproinsulin gene expression in pancreatic beta-cells, but signal transduction pathways and molecular mechanisms underlying this effect are poorly characterized. In this study, we analyzed leptin-mediated signal transduction and preproinsulin gene regulation at the molecular level in pancreatic beta-cells. Leptin stimulation led to janus kinase (JAK)2-depe...

2017
Peter Rotwein

Insulin-like growth factor 1 (IGF1), a small, secreted peptide growth factor, is involved in a variety of physiological and patho-physiological processes, including somatic growth, tissue repair, and metabolism of carbohydrates, proteins, and lipids. IGF1 gene expression appears to be controlled by several different signaling cascades in the few species in which it has been evaluated, with grow...

2007
Valérie Wauthier Pascaline Dubois Roger K. Verbeeck Pedro Buc Calderon

Ageing affects drugs metabolism influencing the therapeutic efficacy and safety of drugs. By using the experimental model of aged male rats, we investigated the influence of ageing on some CYP2C isoforms, the most important CYP450 sub-family in rats. The activity of the male specific CYP2C11 is decreased by 55% in senescent male rats. This correlates with a significant reduction of both protein...

2016
Pier Paolo Leoncini Alice Bertaina Dimitrios Papaioannou Christian Flotho Riccardo Masetti Silvia Bresolin Giuseppe Menna Nicola Santoro Marco Zecca Giuseppe Basso Giovanni Nigita Dario Veneziano Sara Pagotto Katia D'Ovidio Rossella Rota Adrienne Dorrance Carlo M. Croce Charlotte Niemeyer Franco Locatelli Ramiro Garzon

Juvenile myelomonocytic leukemia (JMML) is an aggressive leukemia of early childhood characterized by aberrant proliferation of myelomonocytic cells and hypersensitivity to GM-CSF stimulation. Mutually exclusive mutations in the RAS/ERK pathway genes such as PTPN11, NRAS, KRAS, CBL, or NF1 are found in ~90% of the cases. These mutations give rise to disease at least in part by activating STAT5 ...

Journal: :Molecular endocrinology 1998
S Berchtold S Volarevic R Moriggl M Mercep B Groner

PRL plays a central role in the regulation of milk protein gene expression in mammary epithelial cells and in the growth and differentiation of lymphocytes. It confers its activity through binding to a specific transmembrane, class I hematopoietic receptor. Ligand binding leads to receptor dimerization and activation of the tyrosine kinase Jak (janus kinase) 2, associated with the membrane-prox...

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