نتایج جستجو برای: ژن sry

تعداد نتایج: 17375  

Journal: :Journal of medical genetics 2004
A Sharp K Kusz J Jaruzelska M Szarras-Czapnik J Wolski P Jacobs

T rue hermaphroditism, defined clinically as the presence of both male and female gonadal tissue in the same individual usually accompanied by ambiguous genitalia, is a genetically heterogeneous condition. Less than 10% of true hermaphrodites with an apparent 46,XX constitution are SRY-positive, usually resulting from translocation between Xp and Yp. Previously we described two true hermaphrodi...

2016
D. Rozanska I. Szczerbal M. Stachowiak P. Debiak A. Smiech M. Orzelski B. Zylinska M. Switonski B. Slaska

This is the first report in the literature concerning penile hypoplasia and rudimentary prepuce in a 78,XY; SRY-positive male that received a successful surgical treatment. A six-month-old male mixed-breed dog with body weight of 3.5 kg and with symptoms of prolonged stranguria and abnormalities of the external genitalia were presented by the owner at the University Surgical Clinic. Clinical, b...

Journal: :BioEssays : news and reviews in molecular, cellular and developmental biology 1998
R Jiménez M Burgos

Mammalian sex determination is controlled by the Y-linked gene SRY. Studies of sex-reversed patients and experimental data obtained with mice have identified other genes, such as DAX1, SOX9, SF1, and WT1, which take part in the process, and have suggested how these genes interact to determine the sex of a mammalian embryo. A recent paper in Nature by Swain et al. provides experimental data that...

Journal: :The Journal of Cell Biology 2002
Nicole LeBrasseur

ammalian sex-determining factors with homology to DNA binding proteins are required for splicing, according to a study by Paolo SassoneCorsi and coworkers at the Université Louis Pasteur (Strasbourg, France). Examination of high mobility group (HMG) domain containing SRY and Sox proteins demonstrated a surprising but clear association with splicing complexes. SRY, the testis-determining factor ...

Journal: :Journal of Veterinary Medical Science 1999

Journal: :The Journal of Cell Biology 2002
Nicole LeBrasseur

ammalian sex-determining factors with homology to DNA binding proteins are required for splicing, according to a study by Paolo SassoneCorsi and coworkers at the Université Louis Pasteur (Strasbourg, France). Examination of high mobility group (HMG) domain containing SRY and Sox proteins demonstrated a surprising but clear association with splicing complexes. SRY, the testis-determining factor ...

Journal: :Human reproduction 2001
N Abusheikha A Lass P Brinsden

The case of a 28 year old male with normal male phenotype, in whom repeated seminal analysis showed complete azoospermia, is presented. Peripheral blood culture for chromosome studies revealed 46 chromosomes with XX constitution. Polymerase chain reaction (PCR) analysis of genomic DNA failed to detect the presence of the sex-determining region of the Y chromosome (SRY). A literature review of a...

Journal: :Science 2013
Shunsuke Kuroki Shogo Matoba Mika Akiyoshi Yasuko Matsumura Hitoshi Miyachi Nathan Mise Kuniya Abe Atsuo Ogura Dagmar Wilhelm Peter Koopman Masami Nozaki Yoshiakira Kanai Yoichi Shinkai Makoto Tachibana

Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylas...

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