نتایج جستجو برای: ژن hdac4

تعداد نتایج: 16335  

2017
Edmund A Griffin Philippe A Melas Royce Zhou Yang Li Peter Mercado Kimberly A Kempadoo Stacy Stephenson Luca Colnaghi Kathleen Taylor Mei-Chen Hu Eric R Kandel Denise B Kandel

Addiction to cocaine is commonly preceded by experiences with legal or decriminalized drugs, such as alcohol, nicotine, and marijuana. The biological mechanisms by which these gateway drugs contribute to cocaine addiction are only beginning to be understood. We report that in the rat, prior alcohol consumption results in enhanced addiction-like behavior to cocaine, including continued cocaine u...

Journal: :Journal of autoimmunity 2010
Hanna Maciejewska-Rodrigues Emmanuel Karouzakis Simon Strietholt Hossein Hemmatazad Michel Neidhart Caroline Ospelt Renate E Gay Beat A Michel Thomas Pap Steffen Gay Astrid Jüngel

The aggressive phenotype of RA synovial fibroblasts (RASF) is characterised by the increased expression of matrix metalloproteinase (MMP)-1 as well as the small ubiquitin like modifier (SUMO)-1 and decreased expression of SUMO-specific protease SENP1. Since we showed an increased activity of acetyltransferases in this autoimmune disease, we wanted to analyze whether this affects the expression ...

2017

Submit Manuscript | http://medcraveonline.com Abbreviations: ACTG1: Actin Gamma 1; ARHGDIA: Rho-GDP Dissociation Inhibitor Alpha; BDMR: Brachydactyly-Mental Retardation Syndrome; CMS: Chromosomal Microarray; CNV: Copy Number Variant; FISH: Fluorescence in situ Hybridization; FSCN2: Fascin Actin-Bundling Protein 2, Retinal; TWIST2: Twist-related Protein 2; HDAC4: Histone Deacetylase 4; GPC1: Gly...

ژورنال: یافته 2018
احمدوند, حسن, بهرامی, فرید, فتحی, محمد, پژوهی, ناصر,

Background : Skeletal muscles are composed of various contracted fibrils, which are mainly divided into fast-twitch and slow-twitch. This study aimed to investigate 8 weeks  endurance activity on the MEF2 and HDACA4 gene expression in fast-twitch and slow-twitch  skeletal muscles in male Wistar rats. Materials and Methods: in order to carry out this study, 20 heads of male Wistar rat...

2010
Yuting Sun Yejing Ge Jenny Drnevich Yong Zhao Mark Band Jie Chen

Mammalian target of rapamycin (mTOR) has emerged as a key regulator of skeletal muscle development by governing distinct stages of myogenesis, but the molecular pathways downstream of mTOR are not fully understood. In this study, we report that expression of the muscle-specific micro-RNA (miRNA) miR-1 is regulated by mTOR both in differentiating myoblasts and in mouse regenerating skeletal musc...

2012
Shiro Koizume Shin Ito Etsuko Miyagi Fumiki Hirahara Yoshiyasu Nakamura Yuji Sakuma Hitoshi Osaka Yasuo Takano Wolfram Ruf Yohei Miyagi

Hypoxia-inducible factors (HIF)-1α and HIF2α are major transcription factors required for adaptive responses to hypoxia. HIFs form a complex with aryl hydrocarbon receptor nuclear translocator (ARNT) to bind to the regulatory regions of target genes. The acetylation of histones by histone acetyltransferases (HATs) is one of the epigenetic marks associated with active chromatin. Indeed, HIFs rec...

2012
Juston C. Weems Beth A. Griesel Ann Louise Olson

Insulin-mediated glucose uptake is highly sensitive to the levels of the facilitative glucose transporter protein, GLUT4. Repression of GLUT4 expression is correlated with insulin resistance in adipose tissue. We have shown that differentiation-dependent GLUT4 transcription was under control of class II histone deacetylases (HDACs). We hypothesized that HDACs may regulate gene expression in adi...

Journal: :Molecular cancer therapeutics 2011
Yali Kong Mira Jung Kan Wang Scott Grindrod Alfredo Velena Sung A Lee Sivanesan Dakshanamurthy Yonghong Yang Matthew Miessau Chaoyi Zheng Anatoly Dritschilo Milton L Brown

Inhibitors of histone deacetylases (HDAC) are an important emerging class of drugs for the treatment of cancers. HDAC inhibitors are currently under evaluation in clinical trials as single agents and as sensitizers in combinations with chemotherapies and radiation therapy. Although these drugs have important effects on cancer cell growth and functions, the mechanisms underlying HDAC inhibitor a...

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