نتایج جستجو برای: ژن cyp2d6

تعداد نتایج: 18157  

2016
Dmitry Alekseevich Sychev Mikhail Sergeevich Zastrozhin Valery Valerieevich Smirnov Elena Anatolievna Grishina Ludmila Mikhailovna Savchenko Evgeny Alekseevich Bryun

BACKGROUND Today, it is proved that isoenzymes CYP2D6 and CYP3A4 are involved in metabolism of haloperidol. In our previous investigation, we found a medium correlation between the efficacy and safety of haloperidol and the activity of CYP3A4 in patients with alcohol abuse. OBJECTIVE The aim of this study was to evaluate the correlation between the activity of CYP2D6 and the efficacy and safe...

Journal: :Pharmacological research 2015
Nelson Varela Luis A Quiñones Jana Stojanova Joselyn Garay Dante Cáceres Silvia Cespedes Jaime Sasso Carla Miranda

We tested the influence of four polymorphisms and gene duplication in CYP2D6 on in vivo enzyme activity in a Chilean mestizo population in order to identify the most relevant genetic profiles that account for observed phenotypes in this ethnic group. CYP2D6*2 (2850C>T), *3 (2549A>del), *4 (1846G>A), *17 (1023C>T) and gene duplication were determined by PCR-RFLP or PCRL in a group of 321 healthy...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه سیستان و بلوچستان - دانشکده علوم پایه 1392

چکیده: پیش زمینه: بعضی افراد، به ویژه نسبت به اثرات یک داروی خاص ممکن است حساس، در صورتی که افراد دیگر به آن کاملا مقاوم باشند. با این وجود تفاوتهای فردی در پاسخ به داروها در انسان اغلب ژنتیکی هستند. هدف مطالعه ی حاضر بررسی یکی از پلی مورفیسمهای مهم، cyp2d6*4 می باشد که در متابولیسم بسیاری از دارو ها نقش دارد. روش کار: در این مطالعه نمونه ی dna 300 فرد سالم، که از مرکز پزشکی خاص تهران جمع آور...

Journal: :Drug metabolism and pharmacokinetics 2012
Lay Kek Teh Leif Bertilsson

CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate ...

Journal: :British journal of pharmacy 2022

Gallic acid (GA) is known for its antioxidant activitywhichis restricted due to low oral permeability. In this project the carboxylic group of was substitutedwith sulfonamide and hydroxyl groups were methylated which resulted insignificantly (p<0.01) increased permeability 3,4,5-trimethoxybenzenesulfonamide (TMBS) 3,4,5-trihydroxybenzenesulfonamide (THBS) over GA, inParallel Artificial M...

Introduction: Hyperprolactinemia is a common serious side effect of antipsychotic medications that are currently used in the treatment of patients with schizophrenia. Pharmacogenetic approaches offer the possibility of identifying patient-specific biomarkers for predicting the risk of this side effect. We investigated a possible relationship between variants (SNPs) in genes for cytochrome 2D6 (...

Journal: :The Journal of pharmacology and experimental therapeutics 2000
J A Johnson V L Herring M S Wolfe M V Relling

We have previously shown racial differences in propranolol kinetics, with the largest differences appearing to be in its 4-hydroxylation. The purpose of this study was to identify and confirm the cytochrome P450 enzymes (CYP) with propranolol 4-hydroxylase activity, describe their enzyme kinetics, and determine whether there were racial differences in their catalytic activity. Eleven human reco...

2017
Laura Rabinovich‐Guilatt Lilach Steiner Hussein Hallak Gina Pastino Pierandrea Muglia Ofer Spiegelstein

AIMS Pridopidine is an oral drug in clinical development for treatment of patients with Huntington's disease. This study examined the interactions of pridopidine with in vitro cytochrome P450 activity and characterized the effects of pridopidine on CYP2D6 activity in healthy volunteers using metoprolol as a probe substrate. The effect of food on pridopidine exposure was assessed. METHODS The ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2010
Irene Antolino-Lobo Jan Meulenbelt Sandra M Nijmeijer Peter Scherpenisse Martin van den Berg Majorie B M van Duursen

Metabolism plays an important role in the toxic effects caused by 3,4-methylenedioxymethamphetamine (MDMA). Most research has focused on the involvement of CYP2D6 enzyme in MDMA bioactivation, and less is known about the contribution of other cytochrome P450 (P450) and phase II metabolism. In this study, we researched the differential roles of phase I P450 enzymes CYP1A2, CYP3A4, and CYP2D6 and...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2017
Hitoshi Zembutsu Seigo Nakamura Sadako Akashi-Tanaka Takashi Kuwayama Chie Watanabe Tomoko Takamaru Hiroyuki Takei Takashi Ishikawa Kana Miyahara Hiroshi Matsumoto Yoshie Hasegawa Goro Kutomi Hiroaki Shima Fukino Satomi Minoru Okazaki Hisamitsu Zaha Mai Onomura Ayami Matsukata Yasuaki Sagara Shinichi Baba Akimitsu Yamada Kazuhiro Shimada Daisuke Shimizu Koichiro Tsugawa Arata Shimo Ern Yu Tan Mikael Hartman Ching-Wan Chan Soo Chin Lee Yusuke Nakamura

Purpose: CYP2D6 is the key enzyme responsible for the generation of the potent active metabolite of tamoxifen, "endoxifen." There are still controversial reports questioning the association between CYP2D6 genotype and tamoxifen efficacy. Hence, we performed a prospective multicenter study to evaluate the clinical effect of CYP2D6 genotype on tamoxifen therapy.Experimental Design: We enrolled 27...

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