نتایج جستجو برای: ژن cd44

تعداد نتایج: 22589  

2017
Linda T. Senbanjo Meenakshi A. Chellaiah

CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with appropriate extracellular matrix ligands promotes the migration and invasion processes involved in metastases. It was originally identified as a receptor for hyaluronan or hyaluronic acid and later to several other ligands i...

Journal: :Archives of biochemistry and biophysics 2016
Kenya Terabe Nobunori Takahashi Toki Takemoto Warren Knudson Naoki Ishiguro Toshihisa Kojima

In human osteoarthritic chondrocytes, the hyaluronan receptor CD44 undergoes proteolytic cleavage at the cell surface. CD44 cleavage is thought to require transit of CD44 into cholesterol-rich lipid rafts. The purpose of this study was to investigate whether statins exert a protective effect on articular chondrocytes due to diminution of cholesterol. Three model systems of chondrocytes were exa...

Journal: :Journal of immunology 2002
Katrina Gee Wilfred Lim Wei Ma Devki Nandan Francisco Diaz-Mitoma Maya Kozlowski Ashok Kumar

Alterations in the regulation of CD44 expression play a critical role in modulating cell adhesion, migration, and inflammation. LPS, a bacterial cell wall component, regulates CD44 expression and may modulate CD44-mediated biological effects in monocytic cells during inflammation and immune responses. In this study, we show that in normal human monocytes, LPS and LPS-induced cytokines IL-10 and...

2017
Alpana Sharma

CD44, a single pass transmembrane glycoprotein, initially characterized as lymphocyte homing receptor, has now been implicated in various stages of cancer development. The Anomaly in CD44 expression distinguishes most human cancers. CD44 is also identified as cancer stem cell marker. This review will comprehend the versatile role of CD44 during cancer initiation, proliferation, invasion, metast...

2016
Reza Kaboodkhani Ebrahim Karimi Mohammad Taghi Khorsandi Ashtiani Safoura Kowkabi Mohammad Reza Firouzifar Farzad Yazdani Nasrin Yazdani

INTRODUCTION 90% of the tumors in the head and neck are squamous-cell carcinomas (HNSCC), which have overall 5- year survival rate between 50% -60%. CD44 has been shown to be associated with the prognosis. MATERIALS AND METHODS Biopsy specimens of 51 patients with oral tongue SCC were evaluated by Immunohistochemistry (IHC) for the CD44 antibody. RESULTS There was no significant correlation...

2016
Pu Xia Xiao-Yan Xu

CD44 is a well-recognized stem cell biomarker expressed in colon and gastric cancer. In order to identify whether CD44 mRNA could be used as a prognostic marker in colon and gastric cancer, bioinformatic analyses were used in this study. cBioPortal analysis and COSMIC analysis were used to explore the CD44 mutation. CD44 mRNA levels were evaluated by using SAGE Genie tools and Oncomine analysis...

Journal: :Cancer research 1994
Y J Guo G Liu X Wang D Jin M Wu J Ma M S Sy

Soluble CD44 is present in the serum of normal individuals (2.7 +/- 1.1 nM). The concentration of soluble CD44 in the serum is elevated in patients with advanced gastric (24.2 +/- 9.8 nM) or colon cancer (30.8 +/- 11 nM). Serum CD44 concentration correlated with tumor metastasis and tumor burden. Surgical resection of tumors resulted in decreases in serum CD44 levels. By Western blot analysis, ...

2007

Soluble CD44 is present in the serum of normal individuals (2.7 +_ 1.1 riM). The concentration of soluble CD44 in the serum is elevated in patients with advanced gastric (24.2 + 9.8 riM) or colon cancer (30.8 411 riM). Serum CD44 concentration correlated with tumor metastasis and tumor burden. Surgical resection of tumors resulted in decreases in serum CD44 levels. By Western blot analysis, mon...

Journal: :Cell 2008
Samuel Godar Tan A. Ince George W. Bell David Feldser Joana Liu Donaher Jonas Bergh Anne Liu Kevin Miu Randolph S. Watnick Ferenc Reinhardt Sandra S. McAllister Tyler Jacks Robert A. Weinberg

The p53 tumor suppressor is a key mediator of cellular responses to various stresses. Here, we show that under conditions of basal physiologic and cell-culture stress, p53 inhibits expression of the CD44 cell-surface molecule via binding to a noncanonical p53-binding sequence in the CD44 promoter. This interaction enables an untransformed cell to respond to stress-induced, p53-dependent cytosta...

2013
Adrian Biddle Luke Gammon Bilal Fazil Ian C. Mackenzie

CD44 is commonly used as a cell surface marker of cancer stem-like cells in epithelial tumours, and we have previously demonstrated the existence of two different CD44(high) cancer stem-like cell populations in squamous cell carcinoma, one having undergone epithelial-to-mesenchymal transition and the other maintaining an epithelial phenotype. Alternative splicing of CD44 variant exons generates...

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