Background: The emergence and spread of metallo-beta-lactamase (MBL)-producing Klebsiella pneumoniae are growing global public health concerns. One the most common mechanisms carbapenem resistance is production MBLs, including Verona integron-encoded (VIM), New Delhi (NDM) imipenemase (IMP). Objectives: This study aimed to investigate MBLs among K. isolates. Methods: In this study, 240 isolates...

The emergence of multidrug resistance (MDR) and extensively drug resistance (XDR) in Acinetobacter baumannii has made an important challenge in the treatment of infections caused by this organism. The ability of carbapenemase production is one of the main mechanisms for the emergence of MDR and/or XDR in A. baumannii. The aim of this study was to detect carbapenemase producer A. baumannii. In t...

ObjectivesOur aim was to validate the INCREMENT-CPE score (ICS) in patients hospitalized intensive care unit (ICU) with bacteraemia due carbapenemase-producing Klebsiella pneumoniae (CP-Kp).MethodsThe study conducted ICU of University General Hospital Patras, Greece, during a 10-year period (2010–2019). Patients monomicrobial CP-Kp were included. Primary outcome 14-day mortality. MICs meropenem...

Abstract Background Carbapenem-resistant Gram-negative organisms (CRGNO) are a growing threat. We aimed in our study to determine the genotype of carbapenemases at Beni-Suef University Hospital by using newly introduced lateral flow assays comparison with molecular techniques and test effectiveness ceftazidime/avibactam against them. Methods Screening for carbapenemase production was done mSupe...

Multidrug-resistant (MDR) Klebsiella pneumoniae is increasing worldwide with poorly characterised epidemiology in many parts of the world, particularly Africa. This study aimed to investigate molecular K. pneumoniae, identify diversity sequence types (ST), and detect carbapenem resistance genes major regional hospitals Khartoum, Sudan. isolates (n = 117) were cultured from four April 2015 Octob...