A 40-year-old obese black woman developed abdominal pain with progressive generalized weakness over several days. Physical examination was normal except for several small bruises on her extremities. Laboratory data revealed the following: hemoglobin, 5.0 g/dL; platelet count, 4000/mL; creatinine, 0.8 mg/dL; lactate dehydrogenase, 1364 U/L. Peripheral blood smear revealed many schistocytes. Acqu...

Matrix metalloproteinases (MMPs) have been shown to be key players in both extracellular matrix remodeling and cell migration during cancer metastasis. MMP-14, a membrane-anchored MMP, in particular, is closely associated with these processes. The hemopexin (PEX) domain of MMP-14 has been proposed as the modulating region involved in the molecular cross-talk that initiates cell migration throug...

The role of peroxisomal processes in the maintenance of neurons has not been thoroughly investigated. We propose using Caenorhabditis elegans as a model organism for studying the molecular basis underlying neurodegeneration in certain human peroxisomal disorders, e.g. Zellweger syndrome, since the nematode neural network is well characterized and relatively simple in function. Here we have iden...

We describe a 6-year-old boy who presented with massive hemolysis, shock, disseminated intravascular coagulopathy, and acute renal failure after loxosceles envenomation. In this patient, plasma exchange therapy (PEX) successfully cleared the plasma from an initial hemolytic index of 2000 (equivalent to 2 g/dL hemoglobin, where optimetric laboratory evaluation is impossible) to an index of <50 (...

هدف: هدف پژوهش حاضر، ساخت و اعتبار­سنجی سیاهه آسیب‌شناسی روانشناختی نوجوانان در فضای مجازی بود. روش: روش آمیخته اکتشافی (کیفی-کمی) بدین منظور با استفاده از تحلیل مضمون مقالات مصاحبه‌های انجام‌شده متخصصان فعال مجازی، آسیب­ ها شناسایی شدند بر اساس آن ­ای ساخته شد. جامعه آماری بخش کیفی شامل مقالات، اساتید دانشگاه­ های اراک، اصفهان، امام خمینی قزوین شهر اراک بودند که نمونه هدفمند آنها انتخاب کمی بو...

OBJECTIVE To evaluate the corneal endothelial morphometry and central corneal thickness (CCT) in pseudoexfoliative (PEX) eyes with and without glaucoma and to compare with normal eyes and eyes with primary open-angle glaucoma (POAG). METHOD A total of 166 patients were included in this study: 36 eyes with pseudoexfoliation syndrome (PXS), 30 eyes with pseudoexfoliation glaucoma (PXG), 40 eyes...

Unit test generation tools typically aim at one of two objectives: to explore the program behavior in order to exercise automated oracles, or to produce a representative test set that can be used to manually add oracles or to use as a regression test set. Dynamic symbolic execution (DSE) can efficiently explore all simple paths through a program, exercising automated oracles such as assertions ...

AIMS To evaluate central corneal thickness determined by optical coherence tomography (OCT) in various types of glaucoma, and its influence on intraocular pressure (IOP) measurement. METHODS Central corneal thickness (CCT) was determined by using OCT in 167 subjects (167 eyes). 20 had primary open angle glaucoma (POAG), 42 had low tension glaucoma (LTG), 22 had ocular hypertension (OHT), 10 h...

This article aims to comprehensively describe a particular case of bilateral intraocular subluxated lens with pseudoexfoliation syndrome in Moroccan woman homocystinuria. We report 56-year-old patient who has cataractous along whitish deposits. The association PEX hyperhomocysteinemia rarely been found. It worsens the lenses' zonular stability and causes multiple complications.