PURPOSE Abnormal retinal angiogenesis leads to visual impairment and blindness. Understanding how retinal vessels develop normally has dramatically improved treatments for people with retinal vasculopathies, but additional information about development is required. Abnormal neuron patterning in the outer retina has been shown to result in abnormal vessel development and blindness, for example, ...

The use of design patterns such as the GRASP (General Responsibility Assignment Software Principles) or GoF (Gang-of-Four) patterns in software engineering has been well-documented and widely used in software design and implementation. Research efforts have also been made to apply these generic software engineering design patterns to other design and implementation endeavors in computer science...

The modeling of relationships between motor vehicle crashes and underlying factors has been investigated for more than three decades. Recently, many highway safety studies have documented the use of negative binomial (NB) regression models. On rare occasions, the Poisson model may be the only alternative especially when crash sample mean is low. Pearson's X(2) and the scaled deviance (G(2)) are...

To compare mortality rate, the adjustment of case-mix variables is needed. The Pediatric Index of Mortality (PIM) 3 score is a widely used case-mix adjustment system of a pediatric intensive care unit (ICU), but there has been no validation study of it in Korea. We aim to validate the PIM3 in a Korean pediatric ICU, and extend the validation of the score from those aged 0-16 to 0-18 years, as p...

Context: GoF design patterns are popular among both researchers and practitioners, in the sense that software can be largely comprised of pattern instances. However, there are concerns regarding the efficacy with which software engineers maintain pattern instances, which tend to decay over the software lifetime if no special emphasis is placed on them. Pattern grime (i.e., degradation of the in...

Design patterns were popularized by the GoF catalog in 1995. This catalog contains 23 design patterns which concern 23 design problems. Each pattern is detailed with its structure, its intent, and some information including applicability conditions and some possible variations which enable it to be re-used. In 1995, they were the cutting edge thought processes. We consider that design patterns ...

African American (AA) breast cancer patients often have triple negative breast cancer (TNBC) that contains mutations in the TP53 gene. The point mutations at amino acid residues R273 and R248 both result in oncogenic gain-of-function (GOF) phenotypes. Expression of mutant p53 (mtp53) R273H associates with increased cell elasticity, survival under serum deprivation conditions, and increased Poly...

موضوع مقاله حاضر تاثیر حافظ بر فدریکو گارسیا لورکا یکی از بزرگترین شعرای اسپانیایی است. این پژوهش ابتدا در گذر مختصری معرفی دو شاعر خواننده را با چارچوب فکری و سبک ادبی آشنا می‌سازد چگونگی آشنایی او طریق ترجمه‌هایی که دیوان اسپانیا انجام شده، نشان می ‌دهد. بخش دیگری برای اثبات تاثیرحافظ گفته هایی خود دوستان نزدیک نقل قول می‌شوند؛ آخر تطبیق نمونه‌هایی اشعار میزان مورد ارزیابی قرار می‌گیرد. پذیری...

Exponential random graph models (ERGMs), also known as p* models, have been utilized extensively in the social science literature to study complex networks and how their global structure depends on underlying structural components. However, the literature on their use in biological networks (especially brain networks) has remained sparse. Descriptive models based on a specific feature of the gr...

The Tribolium castaneum homeotic gene maxillopedia (mxp) is the ortholog of Drosophila proboscipedia (pb). Here we describe and classify available mxp alleles. Larvae lacking all mxp function die soon after hatching, exhibiting strong transformations of maxillary and labial palps to legs. Hypomorphic mxp alleles produce less severe transformations to leg. RNA interference with maxillopedia doub...