The objectives of this study were to compare the drug-metabolizing activity of human CYP2D6.24 (I297L), CYP2D6.26 (I369T), CYP2D6.27 (E410K) allelic isoforms with wild-type CYP2D6.1, and to express the CYP2D7 protein derived from an indel polymorphism (CYP2D7 138delT) and investigate its possible codeine O-demethylase activity. Successful creation of individual cDNAs corresponding to CYP2D6*24 ...

The electron stimulated desorption of D anions from deuterated hydrocarbons condensed on a platinum substrate has been studied experimentally. D anion yield functions are reported for incident electron energies ranging from 0 to 20 eV: For each molecule studied, the yield function exhibits a single dissociative attachment resonance at approximately 10 eV: Above 15 eV; a linearly increasing D io...

Donor Agencies/Partners: • PA Consulting Group • Jamaica Hotel and Tourist Association (JHTA) • Jamaica Manufacturers Association (JMA) • Government of Jamaica Ministry of Industry and Tourism • Government of Jamaica National Environment and Planning Agency (NEPA) • Jamaica Bureau of Standards • Tourism Product Development Company (TPDCo) • Government of Jamaica Human Employment and Resource Tr...

Neurofibromatosis type 2 is an often devastating autosomal dominant disorder which, until relatively recently, was confused with its more common namesake neurofibromatosis type 1. Subjects who inherit a mutated allele of the NF2 gene inevitably develop schwannomas, aVecting particularly the superior vestibular branch of the 8th cranial nerve, usually bilaterally. Meningiomas and other benign ce...