Ear l ie r studies from our laboratory demonstra ted tha t the terpolymer of L-glutamic acid, L-alanine, and L-tyrosine (GAT) s t imula ted the development of T cells capable of specifically suppressing the antibody responses in vivo and in vitro of nonresponder s t ra ins (bearing the H-2 "~, H-2 q, and H-2" haplotypes) to GAT complexod with an immunogenic carr ier , methyla tod bovine serum a...

In their review of gelatin tannate (GT) Ruszczyński et al [1] extensively explain tannic acid (TA) activity and they may give the impression that TA is responsible for the mechanism of action of GT and also responsible for the possible adverse effects of the product. Various in vivo studies have demonstrated that GT is a stable complex not dissociated in the small intestine. Therefore any refer...

bordetella pertussis is a gram negative bacterium that causes respiratory tract infection in human (whooping cough). pertussis toxin (pt) is the main component of current acellular pertussis vaccine and the s1 (subunit1) is the main immunogenic part of it. thus, s1 has been the target of many studies as a potent candidate of acellular vaccine against bordetella pertussis, lacking the side effec...

tissue plasminogen activator (tpa) is a serine protease, which is composed of five distinct structural domains with 17 disulfide bonds, representing a model of high-disulfide proteins in human body. one of the most important limitations for high yield heterologous protein production in escherichia coli (e. coli) is the expression of complex proteins with multiple disulfide bridges. in this stud...

background: gold nanoparticles (gnps) are used in imaging and molecular diagnostic applications. as the development of a novel approach in the green synthesis of metal nanoparticles is of great importance and a necessity, a simple and safe method for the synthesis of gnps using plant extracts of zataria multiflora leaves was applied in this study and the results on gnps’ anticancer activity aga...

background: vascular endothelial growth factor (vegf) is a coordinate regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. there are several types of vegf, including vegf165. vegfs stimulate endothelial cell growth, angiogenesis, and capillary permeability. low induction temperature is a major factor for expression of the recombinant vegf165 ...

background: bone morphogenetic proteins (bmps) belong to the transforming growth factor-β (tgf-β) superfamily, and play an important role in bone metabolism. recombinant forms of bmp-2 and bmp-7 are the only bmps used clinically. in this study the mature part of human bone morphogenetic protein-7 (bmp-7) was engineered through substitution of the bmp-7 n-terminal sequence by heparin-binding sit...

background: our study compares the efficacy of the combined contraceptive vaginal ring to oral contraceptive pills (ocps) for hypothalamic-pituitary-ovarian (hpo) axis suppression in egg donor in vitro fertilization (ivf) cycles. methods: our retrospective cohort study includes patients from the center for assisted reproduction (care) in bedford, texas undergoing ivf cycles as egg donors from j...

Geranium thunbergii Sieb. et Zucc. (GT; which belongs to the Geraniaceae family) has been used as a traditional medicine in East Asia for the treatment of inflammatory diseases, including arthritis and diarrhea. However, the underlying mechanisms of the anti-inflammatory effects of GT remain poorly understood. In the present study, we examined the mechanisms responsible for the anti-inflammator...