SAMHD1, a dNTP hydrolase mutated in the autoimmune encephalopathy Aicardi-Goutières syndrome, restricts HIV replication in non-dividing human cells by reducing intracellular deoxyribonucleotide pools. New work in The EMBO Journal unexpectedly finds neither autoimmune disease nor increased murine retrovirus infection in SAMHD1 knockout mice, but improved replication of a mutant HIV with increase...
