نتایج جستجو برای: پروتئین ns3

تعداد نتایج: 20586  

Journal: :F1000Research 2021

Background: Global arterial hypertension (HTA) has increased by 90% over the last four decades, and 1.6% in Peru previous years. This study involved a network analysis of depressive symptomatology Peruvian patients with HTA using estimation. Method: A representative cross-sectional at national level, secondary data from 2019 Demogr...

Journal: :Wellcome open research 2022

Background: The coronavirus disease 2019 (COVID-19) has resulted in an unprecedented research response, demonstrating exceptional examples of rapid and collaboration. There is however a need for greater coordination, with limited resources the shifting global nature pandemic resulting proliferation projects underpowered unable to achieve their aims. <n...

Journal: :F1000Research 2021

Background: Insulin resistance has been independently associated with cardiac diseases. A free fatty acid is recently known to induce insulin due low-grade inflammation. Therefore, the improvement of levels can also improve resistance. This study investigated combination green tea and decaffeinated-light roasted coffee extract in acid-induced by improving adiponectin...

2014
Atsushi Furuta Kazi Abdus Salam Idam Hermawan Nobuyoshi Akimitsu Junichi Tanaka Hidenori Tani Atsuya Yamashita Kohji Moriishi Masamichi Nakakoshi Masayoshi Tsubuki Poh Wee Peng Youichi Suzuki Naoki Yamamoto Yuji Sekiguchi Satoshi Tsuneda Naohiro Noda

Hepatitis C virus (HCV) is an important etiological agent that is responsible for the development of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV nonstructural protein 3 (NS3) helicase is a possible target for novel drug development due to its essential role in viral replication. In this study, we identified halisulfate 3 (hal3) and suvanine as novel NS3 helicase inhibi...

2013
J. Jeremías Incicco Leopoldo G. Gebhard Rodolfo M. González-Lebrero Andrea V. Gamarnik Sergio B. Kaufman

Dengue virus nonstructural protein 3 (NS3) unwinds double stranded RNA driven by the free energy derived from the hydrolysis of nucleoside triphosphates. This paper presents the first systematic and quantitative characterization of the steady-state NTPase activity of DENV NS3 and their interaction with ssRNA. Substrate curves for ATP, GTP, CTP and UTP were obtained, and the specificity order fo...

Journal: :F1000Research 2022

Background: This study aimed to propose an experiential approach for understanding color vision variation using virtual reality technology. Methods: The design was adapted from the phase 1 clinical trial medical apps. A classroom developed in a three-dimensional space, and ten healthy university students were tested understand vari...

Journal: :F1000Research 2023

Background: Infection after fracture fixation (IAFF) associated with an implant in orthopaedic surgery is a feared complication, leading to non-union, loss of function, amputation, and even mortality morbidity the patient. A biofilm formation on surface increases difficulty treatment. Therefore, surgical infection prevention effective antiseptic solution required. Th...

Journal: :Open research Europe 2023

Background: Heating and cooling in buildings represents a significant amount of the energy demand EU, but market penetration renewable solutions is still marginal. The SunHorizon project aims at proving viability benefits innovative coupling between heat pumps various advanced solar panels. Methods:</...

Journal: :F1000Research 2023

Background: The opportunity to completely ‘stop biological time’ using cryopreservation, as it is used in embryo provides for the selection and long-term storage of high-quality preimplantation embryos future usage. While this a beneficial medical procedure, has however posed some legal issues such status an embryo, ownership reproductive autonomy, posthumous reprodu...

Journal: :F1000Research 2021

Background: Access to health services is needed around the world, from healthcare providers doctors. One of needs in public a system that accessible for everyone, but, unequal distribution provider and workers, especially dentistry fields still main problem several countries, including Indonesia. The aim this study analyze spatial dentists, dental technicians, therap...

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