نتایج جستجو برای: پروتئین nrf2

تعداد نتایج: 26324  

Journal: :Investigative ophthalmology & visual science 2008
Ling Wang Yan Chen Paul Sternberg Jiyang Cai

PURPOSE To investigate functional interactions between the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and the nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant system in cultured human retinal pigment epithelium (RPE) cells. METHODS Cultured ARPE-19 cells were treated with different concentrations of PI3K inhibitors, followed by exposure to sulforaphane, an Nrf2 i...

Journal: :Tumori 2012
Eun Mi Je Chang Hyeok An Nam Jin Yoo Sug Hyung Lee

AIMS AND BACKGROUND Nuclear factor erythroid 2-related factor 2 (NRF2) activates expression of cytoprotective proteins such as GCLC and enhances cancer cell survival, whereas KEAP1 inhibits NRF2 by mediating NRF2 degradation. Somatic mutation of NRF2 and KEAP1 genes and loss of KEAP1 expression are detected in many carcinomas and contribute to cancer development. The aim of this study was to se...

2016
Suvi M Kuosmanen Sari Viitala Tuomo Laitinen Mikael Peräkylä Petri Pölönen Emilia Kansanen Hanna Leinonen Suresh Raju Anke Wienecke-Baldacchino Ale Närvänen Antti Poso Merja Heinäniemi Sami Heikkinen Anna-Liisa Levonen

Transcription factor binding specificity is crucial for proper target gene regulation. Motif discovery algorithms identify the main features of the binding patterns, but the accuracy on the lower affinity sites is often poor. Nuclear factor E2-related factor 2 (NRF2) is a ubiquitous redox-activated transcription factor having a key protective role against endogenous and exogenous oxidant and el...

Journal: :Cancer research 2014
Bridgid E Hast Erica W Cloer Dennis Goldfarb Heng Li Priscila F Siesser Feng Yan Vonn Walter Ning Zheng D Neil Hayes Michael B Major

NRF2 is a transcription factor that mediates stress responses. Oncogenic mutations in NRF2 localize to one of its two binding interfaces with KEAP1, an E3 ubiquitin ligase that promotes proteasome-dependent degradation of NRF2. Somatic mutations in KEAP1 occur commonly in human cancer, where KEAP1 may function as a tumor suppressor. These mutations distribute throughout the KEAP1 protein but li...

2015
Mingzhan Xue Hiroshi Momiji Naila Rabbani Guy Barker Till Bretschneider Anatoly Shmygol David A. Rand Paul J. Thornalley

AIMS Stress responsive signaling coordinated by nuclear factor erythroid 2-related factor 2 (Nrf2) provides an adaptive response for protection of cells against toxic insults, oxidative stress and metabolic dysfunction. Nrf2 regulates a battery of protective genes by binding to regulatory antioxidant response elements (AREs). The aim of this study was to examine how Nrf2 signals cell stress sta...

2013
Yu-Kun Jennifer Zhang Kai Connie Wu Curtis D. Klaassen

Acute fasting causes elevated oxidative stress. The current study investigated the effects of the nuclear factor erythoid 2-related factor 2 (Nrf2), the sensor of oxidative stress in cells, on energy homeostasis and liver pathophysiology during fasting. Feed was removed from mice possessing none (Nrf2-null), normal (wild-type, WT), enhanced (Keap1-knockdown, K1-KD), and maximum (hepatocyte-spec...

Journal: :Investigative ophthalmology & visual science 2013
Qing Zhong Manish Mishra Renu A Kowluru

PURPOSE Increase in reactive oxygen species (ROS) is one of the major retinal metabolic abnormalities associated with the development of diabetic retinopathy. NF-E2-related factor 2 (Nrf2), a redox sensitive factor, provides cellular defenses against the cytotoxic ROS. In stress conditions, Nrf2 dissociates from its cytosolic inhibitor, Kelch like-ECH-associated protein 1 (Keap1), and moves to ...

Journal: :Cancer research 2006
Sankaranarayanan Kannan Anil K Jaiswal

Transcription factor NF-E2-related factor 2 (Nrf2) regulates antioxidant response element (ARE)-mediated expression and coordinated induction of chemoprotective proteins in response to chemical stress. In this report, we investigated Nrf2 response to low and high dose UVB irradiation. Low dose (7.5 J/m(2)) UVB exposure of mouse hepatoma, mouse keratinocyte, and human skin fibroblast cells led t...

Journal: :The Journal of biological chemistry 2011
Yumiko Kawai Lakisha Garduño Melanie Theodore Jianqi Yang Ifeanyi J Arinze

Activation of Nrf2 by covalent modifications that release it from its inhibitor protein Keap1 has been extensively documented. In contrast, covalent modifications that may regulate its action after its release from Keap1 have received little attention. Here we show that CREB-binding protein induced acetylation of Nrf2, increased binding of Nrf2 to its cognate response element in a target gene p...

2013
Hongyan Wang Kaihua Liu Miao Geng Peng Gao Xiaoyuan Wu Yan Hai Yangxia Li Yulong Li Lin Luo John D. Hayes Xiu Jun Wang Xiuwen Tang

The transcription factor NRF2 (NFE2L2) is a pivotal activator of genes encoding cytoprotective and detoxifying enzymes that limit the action of cytotoxic therapies in cancer. NRF2 acts by binding antioxidant response elements (ARE) in its target genes, but there is relatively limited knowledge about how it is negatively controlled. Here, we report that retinoic X receptor alpha (RXRa) is a hith...

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