the purpose of this work was to study the effect of various permeation enhancers on the permeation of salbutamol sulphate (ss) buccal patches through buccal mucosa in order to improve the bioavailability by avoiding the first pass metabolism in the liver and possibly in the gut wall and also achieve a better therapeutic effect. the influence of various permeation enhancers, such as dimethyl sul...

Background: Tolmetin (Tol) is a pyrrole acetic acid derivative that acts as a highly effective topical anti-inflammatory agent. Topical administration of Tol is effective for the management of ocular inflammations.The aim of this study was to formulate and improve a topical ophthalmic delivery system of Tol. Materials and methods: In the present study, ocular inserts of Tol were prepared using ...

Buccal mucoadhesive systems among novel drug delivery systems have attracted great attention in recent years due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. Buccal mucoadhesive films can improve the drug therapeutic effect by enhancement of drug absorption through oral mucosa increasing the drug bioavailability via reducing the hepatic f...

Calcium phosphate cement (CPC) sets in situ with intimate adaptation to the contours of defect surfaces, and forms an implant having a structure and composition similar to hydroxyapatite, the putative mineral in teeth and bones. The objective of the present study was to develop an injectable CPC using dicalcium phosphate dihydrate (DCPD) with a high solubility for rapid setting. Two agents were...

Herein the optical properties of Hydroxypropyl methylcellulose/Potassium iodide (HPMC/KI) composite films were determined. The casting technique was introduced to make HPMC/KI with different KI salt concentrations (0.1–1) wt%. absorbance model used determine parameters like absorption edge, refractive index, real and imaginary sections dielectric function, extinction coefficient, Urbach energy,...

The suitability of sunflower oil-hydroxypropyl methylcellulose (HPMC) based oleogel obtained by emulsion template approach as partial cocoa butter (CB) replacer in chocolates was investigated. A level 50% CB replacement optimum, higher affected the sensory appearance comparison to control chocolate (without added oleogel). Four levels HPMC (0.5, 1, 1.5 and 2%) were considered. Textural calorime...

1Department of Pharmaceutics, SriVenkateshwara College of Pharmacy and Research center, Affiliated to Osmania University, Madhapur, Hitech City, Hyderabad500081,Andhra Pradesh, India. A b s t r a c t Sitagliptin phosphate when used alone is an oral anti hyperglycemic drug of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It is available as tablets under trade name JANUVIA. Metformin hydroc...