α2-アンチプラスミン（α2-antiplasmin: α2-AP）は線溶反応の重要な制御因子で，プラスミン活性を阻害するとともに，プラスミノゲンのフィブリンへの集積を抑制することでプラスミン産生も抑制する．α2-APはC端及びN端の翻訳後修飾をそれぞれ受け，4種類の分子種から構成される．α2-APの測定法は，合成基質を用いて残存プラスミン活性を測定する方法であり，即時反応性のプラスミン不活化能を測定するものであるため，全ての分子種のプラスミン阻害能を測定しているものではない．またプラスミノゲンのフィブリン集積抑制効果に対しても十分には反映されているものではない．α2-APが低下している病態では出血傾向を呈するが，先天的に低下している場合と，後天的に低下している場合がある．後天的な低下は肝合成能低下の場合と，線溶活性化に伴う消費性の低下がある．一方，炎症性疾患においてはα2-APは上...

The yeast transcription factor MATα2 (α2) is a short-lived protein known to be ubiquitylated by two distinct pathways, one involving the ubiquitin-conjugating enzymes (E2s) Ubc6 and Ubc7 and the ubiquitin ligase (E3) Doa10 and the other operating with the E2 Ubc4 and the heterodimeric E3 Slx5/Slx8. Although Slx5/Slx8 is a small ubiquitin-like modifier (SUMO)-targeted ubiquitin ligase (STUbL), i...

BACKGROUND The cardiotonic steroid/ouabain-binding site of the α subunit of Na,K-ATPase is thought to play an important role in cardiovascular homeostasis. Previously, we demonstrated the cardiotonic steroid-binding site of the α2 Na,K-ATPase is involved in adrenocorticotropic hormone (ACTH)-induced hypertension by using gene-modified α2(R/R) mice in which the cardiotonic steroid-binding site i...

Overproduction of zinc-α2-glycoprotein by adipose tissue is crucial in accounting for the lipolysis occurring in cancer cachexia of certain malignant tumors. The main aim of this study was to explore whether thyroid hormone could enhance zinc-α2-glycoprotein production in adipose tissue. In addition, the regulation of zinc-α2-glycoprotein by thyroid hormone in the liver was investigated. We per...

and Applied Analysis 3 2. Main Result Our main theorem is given by the following. Theorem 2.1. Let λ0 > 0, 0 < a ≤ 1 max{α1, α2} , |b 1| ≤ 2 α1 α2 , 0 ≤ a − b − 1 ≤ 1 max{α1, α2} . 2.1 If p ∈ P satisfies −2 2 < arg ( λ0 ( p z )a zp′ z ( p z )b ) < γ1π 2 z ∈ U , 2.2 where γj γj a, b, α1, α2 aαj 2 π tan−1 ( α1 α2 /2 cos ( βπ/2 ) cos ( a − b − 1 αjπ/2 ) 2λ0δj a, b, α1, α2 α1 α2 /2 cos ( βπ/2 ) sin...

Endogenous opioids participate in the regulation of gonadotropin secretion through an influence on the release of the hypothalamic LHRH. However, it is not clear whether opioids exert a direct effect on LHRH-producing neurons or interfere with other systems able to influence LHRH release. A neuronal LHRH-producing cell line (GT1) developed recently provides a good model to study the mechanisms ...