Let G be a Jordan domain and K C G be relatively closed with Area(K) = 0. Let A2(G\K) and A2 (G) be the Bergman spaces on G\K, respectively G and define N = A2(G\K) e A2 (G). In this paper we show that with a mild restriction on K, every function in N has an analytic continuation across the analytic arcs of 8G that do not intersect K. This result will be used to discuss the Fredholm theory of t...

Abnormal expression of annexin A2 contributes to metastasis and infiltration of cancer cells. To elucidate the cause of abnormal expression of annexin A2, Western blotting, immunoproteomics and immunohistochemical staining were performed to analyze differentially ubiquitinated proteins between fresh breast cancer tissue and its adjacent normal breast tissue from five female volunteers. We detec...

Let C1 and C2 be algebraic plane curves in C such that the curves intersect in d1 · d2 points where d1, d2 are the degrees of the curves respectively. Oka and Sakamoto proved that π1(C \ C1 ∪ C2)) ∼= π1(C \ C1)× π1(C \ C2) [1]. In this paper we prove the converse of Oka and Sakamoto’s result for line arrangements. Let A1 and A2 be non-empty arrangements of lines in C such that π1(M(A1 ∪ A2)) ∼=...

PURPOSE To investigate the effect of the lipofuscin component N-retinylidene-N-retinylethanolamine (A2-E) on degradative functions of lysosomes in human retinal pigment epithelial (RPE) cells and to evaluate its mechanism of action. METHODS A2-E was coupled to low-density lipoprotein (LDL). Human RPE cell cultures were loaded with the A2-E/LDL complex, and controls were run with medium contai...

BACKGROUND Development of resistance to therapy continues to be a serious clinical problem in lung cancer management. We previously identified that Annexin A2 is significantly up-regulated in cisplatin-resistant non-small cell lung cancer (NSCLC) A549/DDP cells. However, the exact function and molecular mechanism of Annexin A2 in cisplatin resistance of NSCLCs has not been determined. METHODS...

1.16. Again, I’ll only do the triangle inequality. Let x = (a1, . . . , an), y = (b1, . . . , bn), z = (c1, . . . , cn) be three points in Rn, then there is some integer j, 1 ≤ j ≤ n where the max occurs, so that d∞(x, y) = |aj − bj |. Hence, d∞(x, y) = |(aj−cj)+(cj−bj)| ≤ |aj−cj |+|cj−bj | But, |aj−cj | ≤ max{|a1− c1|, . . . , |an − cn|} = d∞(x, z), since it is one of the terms occurring in th...

In the human fetal lung, surfactant protein A (SP-A) is encoded by two highly similar genes, SP-A1 and SP-A2, which are developmentally and hormonally regulated. Using primer extension analysis, we evaluated the levels of SP-A1 and SP-A2 mRNA transcripts in human fetal lung explants and in a human adult lung adenocarcinoma cell line (H441 cells) cultured in the absence or presence of either dib...

To investigate how T cells recognize allogeneic class I proteins encoded by the major histocompatibility complex (MHC), we examined the human cytotoxic T lymphocytes (CTL) elicited in a mixed lymphocyte reaction against a lymphoblastoid B-cell line (JY) whose MHC-class I proteins are HLA-A2 and -B7. By panning the responding T cells on plates that were coated with purified HLA-A2, an essentiall...

Several antigens have been tested as vaccine candidates against Leishmania infections but controversial results have been reported when different antigens are co-administered in combined vaccination protocols. Immunization with A2 or nucleoside hydrolase (NH) antigens was previously shown to induce Th1 immune responses and protection in BALB/c mice against Leishmania donovani and L. amazonensis...

Factor VIIIa, the protein cofactor for factor IXa, is comprised of A1, A2, and A3-C1-C2 subunits. Recently, we showed that isolated A2 subunit enhanced the kcat for factor IXa-catalyzed activation of factor X by approximately 100-fold ( approximately 1 min-1), whereas isolated A1 or A3-C1-C2 subunits showed no effect on this rate (Fay, P. J., and Koshibu, K. J. (1998) J. Biol. Chem. 273, 19049-...