Besides the well-known function of thyroid hormones (THs) for regulating metabolism, it has recently been discovered that THs are also involved in testicular development in mammalian and non-mammalian species. THs, in combination with follicle stimulating hormone, lead to androgen synthesis in Danio rerio, which results in the onset of spermatogenesis in the testis, potentially relating the hyp...

Efficient replication in vivo is essential for a microparasite to colonize its host and the understanding of the molecular mechanisms by which microbial pathogens grow within host tissues can lead to the discovery of novel therapies to treat infection. Here we present evidence that the foodborne bacterial pathogen Listeria monocytogenes, a facultative intracellular parasite, exploits hexose pho...

The nephrotoxic metabolite of the environmental contaminant trichloroethylene, S-(1,2-dichlorovinyl)-l-cysteine (DCVC), is known to elicit cytotoxicity in rat and human proximal tubular (rPT and hPT, respectively) cells that involves inhibition of mitochondrial function. DCVC produces a range of cytotoxic and compensatory responses in hPT cells, depending on dose and exposure time, including ne...

INTRODUCTION White Structure Flaking (WSF) is a type of surface damage responsible for some early failures in wind turbine gearbox bearings. WSF has been associated with microstructural changes registered close to the damaged surface that appear to be white after etching, hence the name White Etching Areas (WEAs). Local hydrogen liberation from lubricants [2] and adiabatic shear bands [3] have...

Introduction Children and adolescents with intellectual disability (ID) have significantly lower levels of physical activity compared to their peers without ID. Association between the level of physical activity and screen time with hypertension (HPT) in children and adolescents with ID has not been reported yet. Aim To assess the relationship between the level of physical activity and screen...

BACKGROUND Intraoperative parathyroid hormone (PTH) monitoring predicts successful surgery for primary hyperparathyroidism (pHPT). In renal HPT, intraoperative PTH assays can define whether parathyroid resection is adequate. METHODS Intraoperative PTH was measured with two different immunometric assays (Immulite Turbo DPC and ADVIA Centaur assay) in 91 patients undergoing parathyroidectomy fo...

BACKGROUND Most patients who have been surgically treated for secondary hyperparathyroidism (HPT) harbor at least one pathological parathyroid gland with a tumor of monoclonal origin. OBJECTIVE To elucidate the underlying genetic mechanisms behind secondary HPT, by studying a panel of such tumors for numerical alterations. METHODS Sixteen parathyroid glands from eight patients (median age 5...

We consider certain constant-coefficient differential operators on Rd that have positive-definite symbols. Each such operator Λ with symbol P defines a semigroup of e−tΛ, t>0, admitting continuous convolution kernel HPt for which the large-time behavior HPt(0) cannot be deduced by basic scaling arguments. The simplest example has P(ξ)=(η+ζ2)2+η4, ξ=(η,ζ)∈R2. devise method allows us to determine...

High-pressure torsion (HPT) is a metal processing method in which the sample is subjected to a very high plastic shear deformation. This process can produce exceptional levels of grain refinement, and provides a corresponding improvement in mechanical properties. To investigate the stress and strain distribution due to HPT process finite element simulation were conducted to investigate effectiv...

Conventional microbiology methods used to detect bacteria include multiple cultures and identification processes, so the results of lab work are painstaking and time-consuming. In recent years, more and more tend to use the diagnostic tests which are based on DNA; hence, DNA diagnostic biosensors have been created to perform DNA identification better. In this study, GUS and hpt genes were used ...