نتایج جستجو برای: نوروتروفینمنتج از مغز bdnf

تعداد نتایج: 710323  

Journal: :Molecular and cellular endocrinology 2010
Erich N Ottem Jessica E Poort Hongbing Wang Cynthia L Jordan S Marc Breedlove

Castration of adult male rats causes dendrites of the spinal nucleus of the bulbocavernosus (SNB) to retract. The neurotrophin brain-derived neurotrophic factor (BDNF) is implicated in mediating these androgenic effects on SNB dendrites. We previously found that castration decreases BDNF mRNA in SNB somata and BDNF protein in proximal SNB dendrites, effects not observed in nearby retrodorsolate...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Kambiz Mousavi Bernard J Jasmin

In skeletal muscle, brain-derived neurotrophic factor (BDNF) has long been thought to serve as a retrograde trophic factor for innervating motor neurons throughout their lifespan. However, its localization in mature muscle fibers has remained elusive. Given the postulated roles of BDNF in skeletal muscle, we performed a series of complementary experiments aimed at defining the localization of B...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
J M Conner J C Lauterborn Q Yan C M Gall S Varon

A sensitive immunohistochemical technique was used, along with highly specific affinity-purified antibodies to brain-derived neurotrophic factor (BDNF), to generate a detailed mapping of BDNF immunoreactivity (BDNF-ir) throughout the adult rat CNS. A parallel analysis of sites of BDNF synthesis was performed with in situ hybridization techniques using a cRNA probe to the exon encoding mature ra...

2017
Pengzhou Hang Jing Zhao Li Sun Minghui Li Yu Han Zhimin Du Yue Li

The clinical application of doxorubicin (Dox) is limited by its adverse effect of cardiotoxicity. Previous studies have suggested the cardioprotective effect of brain-derived neurotrophic factor (BDNF). We hypothesize that BDNF could protect against Dox-induced cardiotoxicity. Sprague Dawley rats were injected with Dox (2.5 mg/kg, 3 times/week, i.p.), in the presence or absence of recombinant B...

Journal: :Thorax 2005
R Staats P Stoll D Zingler J C Virchow M Lommatzsch

BACKGROUND Patients with obstructive sleep apnoea syndrome (OSAS) often display persistent cognitive dysfunction despite effective treatment with continuous positive airway pressure (CPAP). Brain-derived neurotrophic factor (BDNF) is a key mediator of memory and cognition, but its regulation in OSAS and during CPAP treatment is unknown. METHODS Serum and plasma BDNF concentrations, BDNF secre...

Journal: :Genes, brain, and behavior 2007
J M Mercader M Ribasés M Gratacòs J R González M Bayés R de Cid A Badía F Fernández-Aranda X Estivill

Murine models and association studies in eating disorder (ED) patients have shown a role for the brain-derived neurotrophic factor (BDNF) in eating behavior. Some studies have shown association of BDNF -270C/T single-nucleotide polymorphism (SNP) with bulimia nervosa (BN), while BDNF Val66Met variant has been shown to be associated with both BN and anorexia nervosa (AN). To further test the rol...

Journal: :Brain research. Molecular brain research 2004
Malini Sathanoori Brian G Dias Amrita R Nair Sunayana B Banerjee Shubha Tole Vidita A Vaidya

Brain-derived neurotrophic factor (BDNF) is expressed at high levels in the hippocampus, where it has been implicated in physiological functions such as the modulation of synaptic strength as well as in the pathophysiology of epileptic seizures. BDNF expression is highly regulated and the BDNF gene can generate multiple transcript isoforms by alternate splicing of four 5' exons (exons I-IV) to ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Barbara Lom Jeffrey Cogen Analiza Lontok Sanchez Thuy Vu Susana Cohen-Cory

The dendritic and axonal arbors of developing retinal ganglion cells (RGCs) are exposed to two sources of BDNF: RGC dendrites are exposed to BDNF locally within the retina, and RGC axons are exposed to BDNF at the target, the optic tectum. Our previous studies demonstrated that increasing tectal BDNF levels promotes RGC axon terminal arborization, whereas increasing retinal BDNF levels inhibits...

2012
Nicholas A. Castello Kim N. Green Frank M. LaFerla

Brain-derived neurotrophic factor (BDNF) is a neurotrophin critically involved in cell survival, synaptic plasticity, and memory. BDNF has recently garnered significant attention as a potential therapeutic target for neurodegenerative diseases such as Alzheimer disease (AD), but emerging evidence suggests that BDNF may also be mechanistically involved in the pathogenesis of AD. AD patients have...

2015
Shiou-Lan Chen Sheng-Yu Lee Yun-Hsuan Chang Tzu-Yun Wang Shih-Heng Chen Chun-Hsien Chu Po See Chen Yen Kuang Yang Jau-Shyong Hong Ru-Band Lu

BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of long-term heroin use. Thus, we investigated the relationships between brain-derived neurotrophic factor (BDNF) plasma concentrations and the BDNF Val66Met nucleotide polymorphism (SNP) in heroin-dependent patients. The pretreatment expression levels o...

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