نتایج جستجو برای: نمودار کنترل انتخاب عامل انحراف csc
تعداد نتایج: 256079 فیلتر نتایج به سال:
The aim of the present study was to establish cancer stem-like cell/cancer-initiating cell (CSC/CIC)-targeting immunotherapy. The CSC/CIC are thought to be essential for tumor maintenance, recurrence and distant metastasis. Therefore they are reasonable targets for cancer therapy. In the present study, we found that a heat shock protein (HSP) 40 family member, DnaJ (Hsp40) homolog, subfamily B,...
OBJECTIVE To examine results of the multifocal electroretinogram (MERG) after spontaneous resolution of central serous chorioretinopathy (CSC) detachments. METHODS Multifocal electroretinograms were recorded from both eyes of 5 recovered patients with CSC and 10 age-matched healthy subjects. All patients with CSC had bilaterally subnormal MERG amplitudes during a first attack of CSC occuring ...
The inability to target cancer stem cells (CSC) may be a significant factor contributing to treatment failure. We have developed a strategy to target the CSC populations in melanoma and squamous cell carcinoma using CSC lysate-pulsed dendritic cells (DCs). The CSC-DC vaccine was administered in the adjuvant setting after localized radiation therapy of established tumors. Using mouse models we d...
Cancer stem cells or tumor-initiating cells (CSC/TICs), which can undergo self-renewal and differentiation, are thought to play critical roles in tumorigenesis, therapy resistance, tumor recurrence and metastasis. Tumor recurrence and chemoresistance are major causes of poor survival rates of ovarian cancer patients, which may be due in part to the existence of CSC/TICs. Therefore, elucidating ...
کاربرد آلیاژ ti-64 تیتانیوم به سبب خواص منحصر به فرد آن از قبیل سبکی و پایداری در دماهای بالا، در صنایع هوا و فضا گسترش پیدا کرده است. در آلیاژ ti-64 تیتانیوم، رفتار نامعمول مکانیکی از قبیل ناهمسانگردی پلاستیک و عدم تقارن کشش و فشار در جهت های مختلف مشاهده می شود. در این مقاله با انتخاب سطح تسلیم مناسب، کارسختی همسانگرد و روش عددی نگاشت بازگشتی، مدل الاستیک-پلاستیک به روش اجزای محدود پیاده سازی...
We investigated the metabolic profile of cancer stem cells (CSC) isolated from patients with epithelial ovarian cancer. CSC overexpressed genes associated with glucose uptake, oxidative phosphorylation (OXPHOS), and fatty acid β-oxidation, indicating higher ability to direct pyruvate towards the Krebs cycle. Consistent with a metabolic profile dominated by OXPHOS, the CSC showed higher mitochon...
We have recently demonstrated that human Cardiac Stem Cells isolated from explanted failing hearts (E-CSC) are characterized, in vitro, with respect to those isolated from healthy donors (D-CSC), by a senescent phenotype: a reduced telomere length and telomerase activity, telomere erosion, the occurrence of telomere dysfunction foci and the accumulation of senescent markers, as p16INK4A. In thi...
Individual differences in working memory capacity (WMC) are associated with speech recognition in adverse conditions, reflecting the need to maintain and process speech fragments until lexical access can be achieved. When working memory resources are engaged in unlocking the lexicon, there is less Cognitive Spare Capacity (CSC) available for higher level processing of speech. CSC is essential f...
Estradiol (E2) increases not only the cell growth but also the cancer stem cell (CSC) proportion in estrogen receptor (ER)-positive breast cancer cells. It has been suggested that the non-canonical hedgehog (Hh) pathway activated by E2 plays an important role in the regulation of CSC proportion in ER-positive breast cancer cells. We studied anti-CSC activity of a non-canonical Hh inhibitor GANT...
The cancer stem cell (CSC) model posits that CSCs are a small, biologically distinct subpopulation of cancer cells in each tumor that have self-renewal and multi-lineage potential, and are critical for cancer initiation, metastasis, recurrence, and therapy-resistance. Numerous studies have linked CSCs to thyroid biology, but the candidate markers and signal transduction pathways that drive thyr...
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