نتایج جستجو برای: نقض cpt
تعداد نتایج: 8623 فیلتر نتایج به سال:
In healthy subjects with high hypnotisability (highs) under hypnosis, subjectively effective suggestions for analgesia abolish the increases in blood pressure associated with cold pressor test (cpt) by reducing the peripheral vascular resistance. The aim of the present study was to investigate the effects of the suggestions of analgesia on the responses to cpt in healthy highs (n = 22) and in l...
DNA topoisomerase I (Top1p) relaxes supercoiled DNA by the formation of a covalent intermediate in which the active site tyrosine is transiently bound to the severed DNA strand. The antineoplastic agent camptothecin (Cpt) specifically targets Top1p and several mutations have been isolated that render the enzyme Cpt resistant. The mutated residues, although located in different regions of the en...
A glioma is the most common malignant primary brain tumor in adults and categorized according to its growth potential aggressiveness. Within gliomas, grade 4 glioblastoma remains one of lethal solid tumors, with a median survival time less than 18 months. By encapsulating CPT-11 oleic acid-coated magnetic nanoparticles (OMNPs) poly(lactic-co-glycolic acid) (PLGA) nanoparticles, we first prepare...
Purpose: To assess the feasibility of administering camptothecin (CPT), the prototypic topoisomerase I inhibitor, as polyethylene glycol (PEG)-CPT, a macromolecule consisting of CPT conjugated to chemically modified PEG. The study also sought to determine the maximum-tolerated dose (MTD) of PEG-CPT, characterize its pharmacokinetic behavior, and seek preliminary evidence of anticancer activity....
The basis for current clinical trials in the treatment of colorectal cancer with the combination of irinotecan (CPT-11) and 5-fluorouracil (FUra) with or without leucovorin (LV) is their proven activity as single agents, their different mechanisms of action, and lack of CPT-11 cross-resistance to previous FUra/LV treatment. The role of drug dose and administration sequence in this combination w...
X-ray repair cross-complementing gene I protein (XRCC1) in complex with DNA polymerase , DNA ligase III, and poly(ADP-ribose) polymerase is important in the base excision repair process. Previously, we isolated camptothecin (CPT)-resistant cell lines (KB100 and KB300) from the human epidermoid carcinoma cell line KB by exposure to CPT. From these CPT-resistant cell lines, their revertants (KB10...
Possible signals for indirect CPT violation arising in experiments with neutral kaons are considered in the context of a general CPTand Lorentz-violating standard-model extension. Certain CPT observables can depend on the meson momentum and exhibit sidereal variations in time. Any leading-order CPT violation would be controlled by four parameters that can be separately constrained in appropriat...
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