LINKED CONTENT This article is linked to Pol et al and Wang papers. To view these articles, visit https://doi.org/10.1111/apt.16197 https://doi.org/10.1111/apt.16323

OBJECTIVE Prothrombin (PT) is one of the most important antigenic targets for aPL antibodies; however, the prothrombotic mechanism of anti-PT (aPT) antibodies in APS is not fully clarified. Considering that some autoantibodies possess the enzymatic activity, the aim of this study was to test the hypothesis that some aPT antibodies in APS may display prothrombinase activity. METHODS Six APS pa...

Glioblastoma multiforme (GBM), which account for more than 50% of all gliomas, is among the deadliest of all human cancers. Given the dismal prognosis of GBM, it would be advantageous to identify early biomarkers of a response to therapy to avoid continuing ineffective treatments and to initiate other therapeutic strategies. The present in vivo longitudinal study in an orthotopic mouse model de...

We studied 99 patients with systemic autoimmune disease (5 males, 94 women; mean age 37 year, range 16-72): 28 Primary Antiphospholipid Syndrome, 67 Systemic lupus Erythematosus, 1 Mixed Connective Tissue Disease, 2 Undifferentiated Connective Tissue Disease and 1 Discoid Lupus. Based on the observation that native PT shows conformational changes in presence of Ca++ ions and discloses new epito...

Fibronectin extra domain B (EDB) is specifically expressed in cancer-associated blood vessels and extracellular matrix, and thus is a promising cancer biomarker. Very recently, we developed a novel class of high-affinity (<100nM) peptides, termed 'aptides', that specifically bind a variety of protein targets. Here, we describe superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with ...

OBJECTIVES To develop two new models of expedited partner therapy for the UK, and evaluate them for feasibility, acceptability and preliminary outcome estimates to inform the design of a randomised controlled trial (RCT). METHODS Two models of expedited partner therapy (APTHotline and APTPharmacy), known as 'Accelerated Partner Therapy' (APT) were developed. A non-randomised comparative study...

A series of chitosan/attapulgite (CTS/APT) hybrid microspheres were prepared by a facile spray-drying technique. The developed hybrid microspheres were characterized by Fourier transform infrared spectra (FTIR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and the zeta potential. The encapsulation efficiency and in vitro controlled release properties of the microspheres fo...

Ong has shown that the modal mu-calculus model checking problem (equivalently, the alternating parity tree automaton (APT) acceptance problem) of possibly-infinite ranked trees generated by order-n recursion schemes is n-EXPTIME complete. We consider two subclasses of APT and investigate the complexity of the respective acceptance problems. The main results are that, for APT with a single prior...

LINKED CONTENT This article is linked to Khanna &amp; Camilleri and Tobi et al papers. To view these articles, visit https://doi.org/10.1111/apt.16143 https://doi.org/10.1111/apt.16270

LINKED CONTENT This article is linked to Brakenhoff et al and Thibault &amp; Asselah papers. To view these articles, visit https://doi.org/10.1111/apt.16172 https://doi.org/10.1111/apt.16214