Abstract Background Enterobacterales (ENT) are frequently implicated in complicated urinary tract infection, including acute pyelonephritis (cUTI/AP), with Escherichia coli (EC) being the most prevalent. Extended-spectrum β-lactamase (ESBL)-producing organisms increasing and often coresistant to existing oral antibiotics such as fluoroquinolones (FQ) trimethoprim-sulfamethoxazole (TMP-SMX). Teb...